Title | Current Landscape of Ancillary Diagnostic Testing in Chronic Lymphocytic Leukemia. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Geyer JT, Kluk MJ |
Journal | Surg Pathol Clin |
Volume | 16 |
Issue | 2 |
Pagination | 411-421 |
Date Published | 2023 Jun |
ISSN | 1875-9157 |
Keywords | Adult, B-Lymphocytes, Cytogenetic Analysis, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocyte Count, Lymphocytosis |
Abstract | Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is a heterogeneous disease with variable patient outcomes. A multidisciplinary technical evaluation, including flow cytometry, immunohistochemistry, molecular and cytogenetic analyses, can comprehensively characterize a patient's leukemia at diagnosis, identify important prognostic biomarkers, and track measurable residual disease; all of which can impact patient management. This review highlights the key concepts, clinical significance, and main biomarkers detectable with each of these technical approaches; the contents are a helpful resource for medical practitioners involved in the workup and management of patients with CLL. |
DOI | 10.1016/j.path.2023.01.012 |
Alternate Journal | Surg Pathol Clin |
PubMed ID | 37149366 |
Related Faculty:
Julia Geyer, M.D.