Current Landscape of Ancillary Diagnostic Testing in Chronic Lymphocytic Leukemia.

TitleCurrent Landscape of Ancillary Diagnostic Testing in Chronic Lymphocytic Leukemia.
Publication TypeJournal Article
Year of Publication2023
AuthorsGeyer JT, Kluk MJ
JournalSurg Pathol Clin
Volume16
Issue2
Pagination411-421
Date Published2023 Jun
ISSN1875-9157
KeywordsAdult, B-Lymphocytes, Cytogenetic Analysis, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphocyte Count, Lymphocytosis
Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is a heterogeneous disease with variable patient outcomes. A multidisciplinary technical evaluation, including flow cytometry, immunohistochemistry, molecular and cytogenetic analyses, can comprehensively characterize a patient's leukemia at diagnosis, identify important prognostic biomarkers, and track measurable residual disease; all of which can impact patient management. This review highlights the key concepts, clinical significance, and main biomarkers detectable with each of these technical approaches; the contents are a helpful resource for medical practitioners involved in the workup and management of patients with CLL.

DOI10.1016/j.path.2023.01.012
Alternate JournalSurg Pathol Clin
PubMed ID37149366
Related Faculty: 
Michael Kluk, M.D., Ph.D. Julia Geyer, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
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