|Title||A Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis.|
|Publication Type||Journal Article|
|Year of Publication||2021|
|Authors||Showers CR, Nuovo GJ, Lakhanpal A, Siegel CH, Aizer J, Elreda L, Halevi A, Lai AR, Erkan D, Magro CM|
|Keywords||Antibodies, Anticardiolipin, COVID-19, Diabetes Mellitus, Type 2, Female, Humans, Middle Aged, SARS-CoV-2, Thrombosis|
We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient.
|PubMed Central ID||PMC7705934|
Cynthia M. Magro, M.D.