A Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis.

TitleA Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis.
Publication TypeJournal Article
Year of Publication2021
AuthorsShowers CR, Nuovo GJ, Lakhanpal A, Siegel CH, Aizer J, Elreda L, Halevi A, Lai AR, Erkan D, Magro CM
Date Published2021
KeywordsAntibodies, Anticardiolipin, COVID-19, Diabetes Mellitus, Type 2, Female, Humans, Middle Aged, SARS-CoV-2, Thrombosis

We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient.

Alternate JournalPathobiology
PubMed ID33137805
PubMed Central IDPMC7705934
Related Faculty: 
Cynthia M. Magro, M.D.


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