| Title | A Covid-19 Patient with Complement-Mediated Coagulopathy and Severe Thrombosis. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Showers CR, Nuovo GJ, Lakhanpal A, Siegel CH, Aizer J, Elreda L, Halevi A, Lai AR, Erkan D, Magro CM |
| Journal | Pathobiology |
| Volume | 88 |
| Issue | 1 |
| Pagination | 28-36 |
| Date Published | 2021 |
| ISSN | 1423-0291 |
| Keywords | Antibodies, Anticardiolipin, COVID-19, Diabetes Mellitus, Type 2, Female, Humans, Middle Aged, SARS-CoV-2, Thrombosis |
| Abstract | We report a patient with severe Covid-19-associated coagulopathy and type 2 diabetes mellitus who tested positive for antiphospholipid antibodies (aPL). Analysis of skin specimens suggested direct SARS-CoV-2 viral-induced and complement-mediated vascular injury and thrombosis, consistent with prior reports. Serial aPL testing demonstrated high levels of anticardiolipin antibodies (aCL) that declined to insignificant levels over a period of 5 weeks. SARS-CoV-2 RNA was detected in nasopharyngeal swab specimens on serial assays performed over the same 5-week period, though it was not detected thereafter. We hypothesize that SARS-CoV-2 viral-induced aPL contributed to severe Covid-19-associated coagulopathy in this patient. |
| DOI | 10.1159/000512503 |
| Alternate Journal | Pathobiology |
| PubMed ID | 33137805 |
| PubMed Central ID | PMC7705934 |
Related Faculty:
Cynthia M. Magro, M.D.