Clinicopathologic and Molecular Features of Pancreatic Ductal Adenocarcinomas Harboring Alterations in COMPASS-like Complex Genes.

TitleClinicopathologic and Molecular Features of Pancreatic Ductal Adenocarcinomas Harboring Alterations in COMPASS-like Complex Genes.
Publication TypeJournal Article
Year of Publication2023
AuthorsHissong E, Zhao L, Shi J
JournalArch Pathol Lab Med
Date Published2023 Sep 01
KeywordsAdenocarcinoma, Carcinoma, Pancreatic Ductal, Carcinoma, Squamous Cell, Epigenesis, Genetic, Humans, Mutation, Pancreatic Neoplasms

CONTEXT.—: Recent genome-wide sequencing studies have identified a subset of pancreatic ductal adenocarcinomas (PDACs) harboring significant alterations in epigenetic regulation genes, including the COMPASS-like complex genes. Whether this subset of PDACs has specific histologic characteristics or carries prognostic or therapeutic implications is unknown.

OBJECTIVE.—: To determine the specific clinicopathologic and molecular features of PDACs carrying mutations in COMPASS-like complex genes.

DESIGN.—: We analyzed a series of 103 primary and metastatic PDACs with comprehensive molecular profiling, including 13 PDACs carrying loss-of-function COMPASS-like complex gene alterations (study cohort). Another 45 patients carrying PDACs with wild-type COMPASS-like complex genes were used as the control group.

RESULTS.—: PDACs within the study cohort were smaller, harboring frequent areas of poor differentiation and concurrent alterations in KRAS, TP53, SMAD4, and CDKN2A. A subset of metastatic PDACs from the study cohort showed squamous differentiation. There was a trend toward decreased survival in the study group. We further interrogated 2 public data sets and found that PDACs with COMPASS-like complex gene alterations have increased rates of TP53 mutation, body-tail location, poor differentiation or undifferentiated histology, and a higher death rate.

CONCLUSIONS.—: COMPASS-like complex gene alterations likely represent a subset of more aggressive PDACs with poor or squamous differentiation histologically and increased concurrent TP53 mutations. These findings may have potential prognostic and therapeutic implications.

Alternate JournalArch Pathol Lab Med
PubMed ID36508685
PubMed Central IDPMC10261500
Grant ListK08 CA234222 / CA / NCI NIH HHS / United States
R37 CA262209 / CA / NCI NIH HHS / United States
Related Faculty: 
Erika Hissong, M.D.

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