Cellular immunity in patients with systemic juvenile rheumatoid arthritis.

TitleCellular immunity in patients with systemic juvenile rheumatoid arthritis.
Publication TypeJournal Article
Year of Publication1987
AuthorsTsokos GC, Mavridis A, Inghirami G, Pillemer SR, Emery HM, Magilavy DB
JournalClin Immunol Immunopathol
Date Published1987 Jan
KeywordsAdolescent, Arthritis, Juvenile, B-Lymphocytes, Child, Child, Preschool, Concanavalin A, Female, Hemolytic Plaque Technique, Humans, Immunity, Cellular, Lymphocyte Activation, Male, Pokeweed Mitogens, T-Lymphocytes

We studied the cellular immune responses in 10 patients with systemic form of juvenile rheumatoid arthritis. The numbers of peripheral T lymphocytes and their helper/inducer and cytotoxic/suppressor subpopulation were within normal levels. Activated T lymphocytes (DR+) were slightly increased but not at statistically significant levels. In contrast to the T cells, B lymphocytes were increased; both the percentage of B cells (B1+) and the number of cells spontaneously secreting IgG, IgA, and IgM were increased. Stimulation of peripheral mononuclear cells in vitro with pokeweed mitogen induced poor plaque-forming cell responses, which were partially improved upon removal of monocytes. The presence of concanavalin A in the cultures led to complete suppression. We conclude that patients with systemic JRA are characterized primarily by B-cell rather than T-cell abnormalities.

Alternate JournalClin Immunol Immunopathol
PubMed ID3539432
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Giorgio Inghirami, M.D.

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