B-cell neoplasms and Hodgkin lymphoma in the spleen.

TitleB-cell neoplasms and Hodgkin lymphoma in the spleen.
Publication TypeJournal Article
Year of Publication2021
AuthorsGeyer JT, Prakash S, Orazi A
JournalSemin Diagn Pathol
Volume38
Issue2
Pagination125-134
Date Published2021 Mar
ISSN0740-2570
Abstract

B-cell lymphoma of spleen may be primary (most commonly splenic diffuse large B-cell lymphoma) or secondary (typically low-grade non-Hodgkin lymphoma). Depending on the specific lymphoma subtype, there may be a predominantly white pulp pattern of involvement, a predominantly red pulp pattern or a focal nodular pattern. Splenectomy is the ideal specimen for a multiparametric integrative diagnosis of splenic lymphoma, as it allows for a combined study of morphology, immunohistology, flow cytometry, cytogenetics, and molecular genetic techniques. This review article describes the clinicopathologic characteristics of all the relevant B-cell neoplasms that may be encountered in a splenic biopsy or a splenectomy specimen.

DOI10.1053/j.semdp.2020.08.002
Alternate JournalSemin Diagn Pathol
PubMed ID32839024
Related Faculty: 
Julia Geyer, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700