| Title | AID is required for c-myc/IgH chromosome translocations in vivo. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC |
| Journal | Cell |
| Volume | 118 |
| Issue | 4 |
| Pagination | 431-8 |
| Date Published | 2004 Aug 20 |
| ISSN | 0092-8674 |
| Keywords | Animals, B-Lymphocytes, Cell Separation, Chromosomes, Cytidine Deaminase, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunoglobulin G, Immunoglobulins, Interleukin-6, Mice, Mice, Inbred BALB C, Mice, Transgenic, Models, Genetic, Polymerase Chain Reaction, Protein Transport, Proto-Oncogene Proteins c-myc, Time Factors, Translocation, Genetic |
| Abstract | Chromosome translocations between c-myc and immunoglobulin (Ig) are associated with Burkitt's lymphoma in humans and with pristane- and IL6-induced plasmacytomas in mice. These translocations frequently involve Ig switch regions, suggesting that they might be the result of aberrant Ig class switch recombination (CSR). However, a direct link between CSR and chromosome translocations has not been established. We have examined c-myc/IgH translocations in IL6 transgenic mice that are mutant for activation induced cytidine deaminase (AID), the enzyme that initiates CSR. Here we report that AID is essential for the c-myc/IgH chromosome translocations induced by IL6. |
| DOI | 10.1016/j.cell.2004.08.006 |
| Alternate Journal | Cell |
| PubMed ID | 15315756 |
Related Lab:
Related Faculty:
Selina Chen-Kiang, Ph.D.