Title | Kaposi sarcoma-associated herpesvirus in non-Hodgkin lymphoma and reactive lymphadenopathy in Uganda. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Engels EA, Mbulaiteye SM, Othieno E, Gomez M, Mathew S, Cesarman E, Knowles DM, Chadburn A |
Journal | Hum Pathol |
Volume | 38 |
Issue | 2 |
Pagination | 308-14 |
Date Published | 2007 Feb |
ISSN | 0046-8177 |
Keywords | Antigens, Viral, Child, Preschool, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Herpesvirus 8, Human, Humans, Immunohistochemistry, In Situ Hybridization, Lymphatic Diseases, Lymphoma, B-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Non-Hodgkin, Male, Nuclear Proteins, Sarcoma, Kaposi, Uganda |
Abstract | Kaposi sarcoma-associated herpesvirus (KSHV) causes Kaposi sarcoma and is also associated with primary effusion lymphoma, a subset of diffuse large B-cell lymphomas, and multicentric Castleman disease. Because KSHV infection is endemic in sub-Saharan Africa, we sought to identify cases of KSHV-positive non-Hodgkin lymphomas (NHLs) and reactive lymphadenopathy in this region. One hundred forty-four cases (80 NHLs, 64 reactive lymph nodes) from the major pathology laboratory in Uganda were reviewed. One NHL was KSHV-positive, as indicated by staining for the viral latent nuclear antigen. This NHL was a diffuse large B-cell lymphoma in a 5-year-old boy. The tumor was also Epstein-Barr virus-positive. In addition, 2 reactive lymph nodes, both classified histologically as follicular involution, stained KSHV latent nuclear antigen-positive and thus most likely represent multicentric Castleman disease. In all 3 KSHV-positive cases, a minority of cells expressed KSHV viral interleukin 6, a biologically active cytokine homolog. In conclusion, we show that KSHV is rarely associated with lymphoproliferative disorders in sub-Saharan Africa. We describe the first case of a KSHV-positive NHL from this region; this case is also the first reported pediatric lymphoma associated with KSHV infection. |
DOI | 10.1016/j.humpath.2006.08.009 |
Alternate Journal | Hum Pathol |
PubMed ID | 17097130 |
Related Faculty:
Amy Chadburn, M.D. Ethel Cesarman, M.D., Ph.D.