| Title | Human embryonic stem cell derivation from poor-quality embryos. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Lerou PH, Yabuuchi A, Huo H, Takeuchi A, Shea J, Cimini T, Ince TA, Ginsburg E, Racowsky C, Daley GQ |
| Journal | Nat Biotechnol |
| Volume | 26 |
| Issue | 2 |
| Pagination | 212-4 |
| Date Published | 2008 Feb |
| ISSN | 1546-1696 |
| Keywords | Cell Culture Techniques, Cell Differentiation, Cell Survival, Cells, Cultured, Embryo, Mammalian, Embryonic Stem Cells, Humans |
| Abstract | During in vitro fertilization, embryos deemed clinically useless based on poor morphology are typically discarded. Here we demonstrate a statistical correlation between the developmental stage of such poor-quality embryos and the yield of human embryonic stem (hES) cell lines. Early-arrested or highly fragmented embryos only rarely yield cell lines, whereas those that have achieved blastocyst stage are a robust source of normal hES cells. |
| DOI | 10.1038/nbt1378 |
| Alternate Journal | Nat Biotechnol |
| PubMed ID | 18223642 |
Related Faculty:
Tan Ince, M.D., Ph.D.