Title | Detection of T lymphocytes specific for human endogenous retrovirus K (HERV-K) in patients with seminoma. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Rakoff-Nahoum S, Kuebler PJ, Heymann JJ, Sheehy ME, Ortiz GM, Ogg GS, Barbour JD, Lenz J, Steinfeld AD, Nixon DF |
Journal | AIDS Res Hum Retroviruses |
Volume | 22 |
Issue | 1 |
Pagination | 52-6 |
Date Published | 2006 Jan |
ISSN | 0889-2229 |
Keywords | Antibodies, Viral, Endogenous Retroviruses, Female, Humans, Male, Middle Aged, Seminoma, T-Lymphocytes, Virus Integration |
Abstract | Human endogenous retrovirus K (HERV-K) is distinctive among the retroviruses that comprise about 8% of the human genome in that multiple HERV-K proviruses encode full-length viral proteins, and many HERV-K proviruses formed during recent human evolution. HERV-K gag proteins are found in the cytoplasm of primary tumor cells of patients with seminoma. We identified HERV-K-specific T cells in patients with a past history of seminoma using the interferon-gamma ELISPOT assay and an MHC-HERV-K peptide-specific tetramer. A minority of apparently healthy subjects without evident germ cell tumors also made HERV-K-specific T cell responses. In summary, we detected T cell reactivity to HERV-K peptides in both past seminoma patients and a minority of apparently healthy controls. |
DOI | 10.1089/aid.2006.22.52 |
Alternate Journal | AIDS Res Hum Retroviruses |
PubMed ID | 16438646 |
Grant List | R01-AI44595 / AI / NIAID NIH HHS / United States |
Related Faculty:
Jonas Heymann, M.D.