| Title | IGF-1 activates p21 to inhibit UV-induced cell death. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Murray SA, Zheng H, Gu L, Xiao Z-XJim |
| Journal | Oncogene |
| Volume | 22 |
| Issue | 11 |
| Pagination | 1703-11 |
| Date Published | 2003 Mar 20 |
| ISSN | 0950-9232 |
| Keywords | Animals, Apoptosis, Cyclin-Dependent Kinase Inhibitor p21, Cyclins, Down-Regulation, Humans, Insulin-Like Growth Factor I, Mice, Nuclear Proteins, Phosphatidylinositol 3-Kinases, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, Proto-Oncogene Proteins c-mdm2, Tumor Cells, Cultured, Ultraviolet Rays, Up-Regulation |
| Abstract | The insulin-like growth factor-1 (IGF-1) and its downstream effector Akt have been documented as survival factors in response to a variety of stress signals. In this study, we show that IGF-1 activates p21 protein expression in a p53-dependent manner. Inhibition of PI-3 kinase or ectopic expression of a dominant-negative Akt blocks the effect of IGF-1 on the upregulation of p21 expression. In addition, IGF-1 prevents the UV irradiation-mediated suppression of p21 and MDM2 expression. Furthermore, p21 is important for IGF-1-mediated cell survival upon UV irradiation. Taken together, these data indicate that IGF-1 may activate p21 in executing its survival function upon genotoxic insults. |
| DOI | 10.1038/sj.onc.1206327 |
| Alternate Journal | Oncogene |
| PubMed ID | 12642873 |
| Grant List | R01CA79804 / CA / NCI NIH HHS / United States |
Related Faculty:
Hongwu Zheng, Ph.D.