Title | De novo intraepidermal epithelioid melanocytic dysplasia as a marker of the atypical mole phenotype -- a clinical and pathological study of 75 patients. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Sachdeva M, Frambach GE, A Crowson N, Deng AC, Mihm MC, Magro CM |
Journal | J Cutan Pathol |
Volume | 32 |
Issue | 9 |
Pagination | 622-8 |
Date Published | 2005 Oct |
ISSN | 0303-6987 |
Keywords | Adolescent, Adult, Aged, Aged, 80 and over, Child, Diagnosis, Differential, Epithelioid Cells, Female, Humans, Male, Melanocytes, Middle Aged, Nevus, Pigmented, Phenotype, Skin Diseases |
Abstract | BACKGROUND: We encountered a distinctive pattern of dysplastic intraepidermal melanocytic proliferation, which defies classification as a dysplastic melanocytic nevus, but in which the morphologic features fall short of a diagnosis of melanoma in situ. We designate such lesions as de novo intraepidermal epithelioid melanocytic dysplasia. METHODS: From 75 patients, 82 skin biopsies were encountered that showed this distinctive morphology. Hematoxylin- and eosin-stained histologic sections were studied and the features were correlated with personal and family histories of dysplastic nevi and melanoma. RESULTS: The diagnosis of de novo melanocytic dysplasia was made in 27 male patients and 48 female patients (mean age: 44 years). The histologic hallmark was a pagetoid (single-cell) array of moderately to severely atypical epithelioid melanocytes within the epidermis. Seventy-three lesions were located on sun-exposed skin and nine on sun-protected skin. In 41 patients, there was an atypical mole phenotype, whereas 20 patients had a prior or subsequent diagnosis of melanoma with five of 16 patients questioned revealing a family history of melanoma. CONCLUSIONS: De novo intraepidermal epithelioid melanocytic dysplasia is a distinct entity associated with an atypical mole phenotype and a personal and/or family history of melanoma. |
DOI | 10.1111/j.0303-6987.2005.00314.x |
Alternate Journal | J Cutan Pathol |
PubMed ID | 16176300 |
Related Faculty:
Cynthia M. Magro, M.D.