Title | Cutaneous CD4+ CD56+ hematologic malignancies. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Magro CM, Porcu P, Schaefer J, Erter JW, Furman RR, Shitabata PK, A Crowson N |
Journal | J Am Acad Dermatol |
Volume | 63 |
Issue | 2 |
Pagination | 292-308 |
Date Published | 2010 Aug |
ISSN | 1097-6787 |
Keywords | Adult, Aged, Biopsy, CD4 Antigens, CD56 Antigen, Dendritic Cells, Fatal Outcome, Hematologic Neoplasms, Humans, Immunophenotyping, Killer Cells, Natural, Leukemia, Myeloid, Acute, Leukemia, T-Cell, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Male, Middle Aged, Mycosis Fungoides, Sarcoma, Myeloid, Skin Neoplasms |
Abstract | BACKGROUND: Hematologic malignancies expressing CD4 and CD56 are most commonly associated with the recently described CD4(+) CD56(+) hematodermic neoplasm. METHODS: Thirteen cases of CD4(+) CD56(+) hematologic malignancies were prospectively encountered in the routine and referral practices of the authors. RESULTS: Patients 1 and 2 were elderly men exhibiting an acute onset of skin, bone-marrow, and peripheral blood involvement, both dying of their disease within less than 12 months. CD3(+) phenotype and a clonal T-cell receptor beta rearrangement indicated categorization as a CD4(+) natural killer T-cell lymphoma. Patient 3 developed a CD56(+) anaplastic large cell lymphoma and is without disease after excision and radiation. Indolent CD4(+) CD56(+) poikilodermatous mycosis fungoides defined case 4. There were 7 patients with CD123(+) CD4(+) CD56(+) hematodermic neoplasm, 4 dying within 18 months of presentation with peripheral blood/marrow involvement in 6 of the 7 cases. Two patients with granulocytic sarcoma dying within 100 days of presentation defined the last two cases. LIMITATIONS: There were relatively small numbers in each of the categories and the follow-up was limited in those cases where death was not reported. CONCLUSION: Cutaneous malignancies composed of CD4(+) CD56(+) hematopoietic cells define a varied group and oftentimes have an aggressive clinical course although not in every case. |
DOI | 10.1016/j.jaad.2009.08.044 |
Alternate Journal | J Am Acad Dermatol |
PubMed ID | 20541283 |
Related Faculty:
Cynthia M. Magro, M.D.