Title | Frequent truncating mutations of STAG2 in bladder cancer. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Solomon DA, Kim J-S, Bondaruk J, Shariat SF, Wang Z-F, Elkahloun AG, Ozawa T, Gerard J, Zhuang D, Zhang S, Navai N, Siefker-Radtke A, Phillips JJ, Robinson BD, Rubin MA, Volkmer B, Hautmann R, Küfer R, Hogendoorn PCW, Netto G, Theodorescu D, C James D, Czerniak B, Miettinen M, Waldman T |
Journal | Nat Genet |
Volume | 45 |
Issue | 12 |
Pagination | 1428-30 |
Date Published | 2013 Dec |
ISSN | 1546-1718 |
Keywords | Animals, Antigens, Nuclear, Cell Cycle Proteins, Cell Line, Tumor, Codon, Nonsense, Female, Gene Frequency, Humans, Mice, Mice, Inbred BALB C, Mice, Nude, Neoplasm Invasiveness, Urinary Bladder Neoplasms, Urothelium |
Abstract | Here we report the discovery of truncating mutations of the gene encoding the cohesin subunit STAG2, which regulates sister chromatid cohesion and segregation, in 36% of papillary non-invasive urothelial carcinomas and 16% of invasive urothelial carcinomas of the bladder. Our studies suggest that STAG2 has a role in controlling chromosome number but not the proliferation of bladder cancer cells. These findings identify STAG2 as one of the most commonly mutated genes in bladder cancer. |
DOI | 10.1038/ng.2800 |
Alternate Journal | Nat Genet |
PubMed ID | 24121789 |
Grant List | R21CA143282 / CA / NCI NIH HHS / United States / ImNIH / Intramural NIH HHS / United States P50CA091846 / CA / NCI NIH HHS / United States R01CA169345 / CA / NCI NIH HHS / United States R01CA159467 / CA / NCI NIH HHS / United States |
Related Faculty:
Brian Robinson, M.D.