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Dr. Di Lorenzo’s laboratory is interested in two major area of research: one is to define the molecular mechanisms by which endothelial nitric oxide synthase (eNOS)-derived NO controls the endothelial barrier functions to the passage of plasma molecules and inflammatory cells.Another area of research focuses on the role of Nogo-B, belonging to the Reticulon-4 family of proteins expressed in the ER, in vascular function regulation and in cardiac hypertrophy development.
Active Projects
- To study the role of eNOS in vascular permeability and inflammatory cell recruitment to the site of inflammation.
- To investigate the role of Nogo-B in vascular function and cardiac hypertrophy.
Active Grants
- Endothelial sphingolipid synthesis and tissue inflammatory response
PI: Dr. Annarita Di Lorenzo, PhD
National Institutes of Health (NIH) - Endothelial-derived Sphingolipids in Coronary Atherosclerosis
PI: Annarita Di Lorenzo, PhD
Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research - Role of Nitric Oxide (NO) in Regulating VE-Cadherin Biological Functions
PI: Annarita Di Lorenzo, PhD
American Heart Association (AHA)
Selected Publications
Sphingolipids: Fats That Protect The Heart
Annarita Di Lorenzo, PhD
Sphingolipids: Fats That Protect The Heart
Scientia. Sep 13, 2017
Di Lorenzo A.
http://www.scientia.global/dr-annarita-di-lorenzo-sphingolipids-fats-protect-heart/
SciPod. October 2017
Di Lorenzo A.
http://www.scipod.global/sphingolipids-fats-that-protect-the-heart-dr-annarita-di-lorenzo-cornell-university/
Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice
Domenick J. Falcone, PhD
Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice
Cancer Prev Res (Phila). 2015 Aug;8(8):751-9.
Bhardwaj P, Du B, Zhou XK, Sue E, Giri D, Harbus MD, Falcone DJ, Hudis CA, Subbaramaiah K, Dannenberg AJ.
PMID: 26038116; PMCID: PMC4526346
Read MoreMenopause is a determinant of breast adipose inflammation
Domenick J. Falcone, PhD
Menopause is a determinant of breast adipose inflammation
Cancer Prev Res (Phila). 2015 May;8(5):349-58.
Iyengar NM, Morris PG, Zhou XK, Gucalp A, Giri D, Harbus MD, Falcone DJ, Krasne MD, Vahdat LT, Subbaramaiah K, Morrow M, Hudis CA, Dannenberg AJ.
PMID: 25720743; PMCID: PMC4417434
Read MoreHIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis
Annarita Di Lorenzo, PhD
HIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis
Hypertension. 2013 Sep;62(3):634-40.
Huang Y, Di Lorenzo A, Jiang W, Cantalupo A, Sessa WC, Giordano FJ.
PMID: 23918749
Read MoreCaloric restriction reverses obesity-induced mammary gland inflammation in mice.
Domenick J. Falcone, PhD
Caloric restriction reverses obesity-induced mammary gland inflammation in mice.
Cancer Prev Res (Phila). 2013 Apr;6(4):282-9.
Bhardwaj P, Du B, Zhou XK, Sue E, Harbus MD, Falcone DJ, Giri D, Hudis CA, Kopelovich L, Subbaramaiah K, Dannenberg AJ.
PMID: 23430756
Read MoreAntagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.
Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.
J Biol Chem. 2013 Feb 15;288(7):4908-21.
Chang SH, Lu YC, Li X, Hsieh WY, Xiong Y, Ghosh M, Evans T, Elemento O, Hla T.
PMID: 23223443; PMCID: PMC3576095
Read MoreSphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.
Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.
J Biol Chem. 2013 Jan 25;288(4):2143-56.
Mendelson K, Zygmunt T, Torres-Vázquez J, Evans T, Hla T.
PMID: 23229546
Read MoreThe annexin A2/S100A10 system in health and disease: emerging paradigms.
Domenick J. Falcone, PhD
The annexin A2/S100A10 system in health and disease: emerging paradigms.
J Biomed Biotechnol. 2012;2012:406273.
Hedhli N, Falcone DJ, Huang B, Cesarman-Maus G, Kraemer R, Zhai H, Tsirka SE, Santambrogio L, Hajjar KA.
PMID: 23193360
Read MoreFlow-regulated endothelial S1P receptor-1 signaling sustains vascular development.
Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.
Dev Cell. 2012 Sep 11;23(3):600-10.
Jung B, Obinata H, Galvani S, Mendelson K, Ding BS, Skoura A, Kinzel B, Brinkmann V, Rafii S, Evans T, Hla T.
PMID: 22975328; PMCID: PMC3443394
Read MoreMatrix metalloproteinase (MMP)-dependent microsomal prostaglandin E synthase (mPGES)-1 expression in macrophages: Role of TNF-α and the EP4 prostanoid receptor
Domenick J. Falcone, PhD
Matrix metalloproteinase (MMP)-dependent microsomal prostaglandin E synthase (mPGES)-1 expression in macrophages: Role of TNF-α and the EP4 prostanoid receptor
J Immunol. 2012 Feb 15;188(4):1970-80.
Khan KM, Kothari P, Du B, Dannenberg AJ, Falcone DJ.
PMID: 22227567
Read MoreSnapShot: Bioactive lysophospholipids.
SnapShot: Bioactive lysophospholipids.
Cell. 2012 Jan 20;148(1-2):378-378.e2.
Moolenaar WH, Hla T.
PMID: 22265422
Read MoreProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation
Domenick J. Falcone, PhD
ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation
J Exp Med. 2012 Nov 19;209(12):2291-305.
Siao CJ, Lorentz CU, Kermani P, Marinic T, Carter J, McGrath K, Padow VA, Mark W, Falcone DJ, Cohen-Gould L, Parrish DC, Habecker BA, Nykjaer A, Ellenson LH, Tessarollo L, Hempstead BL.
PMID: 23091165; PMCID: PMC3501352
Read MoreNormal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function
Annarita Di Lorenzo, PhD
Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17478-83.
Huang Y, Lei L, Liu D, Jovin I, Russell R, Johnson RS, Di Lorenzo A, Giordano FJ.
PMID: 23047702; PMCID: PMC3491491
Read MoreInflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer
Domenick J. Falcone, PhD
Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer
Cancer Prev Res (Phila). 2011 Jul;4(7):1021-9.
Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK, Du B, Brogi E, Crawford CB, Kopelovich L, Subbaramaiah K, Dannenberg AJ.
PMID: 21622727; PMCID: PMC3131426
Read MoreEndothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8.
Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B.
PMID: 21606363; PMCID: PMC3111292
Read MoreEngagement of S1P₁-degradative mechanisms leads to vascular leak in mice
Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice
J Clin Invest. 2011 Jun;121(6):2290-300.
Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, Blaho V, Hwang SI, Han DK, Hla T.
PMID: 21555855
Read MoreMacrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification.
Domenick J. Falcone, PhD
Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification.
Carcinogenesis. 2011 May;32(5):695-702.
Hou Z, Falcone DJ, Subbaramaiah K, Dannenberg AJ.
PMID: 21310944
Read MoreSmooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.
Annarita Di Lorenzo, PhD
Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.
PLoS One. 2011 Apr 22;6(4):e18869.
Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC.
PMID: 21526127
Read MoreEndothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation
Annarita Di Lorenzo, PhD
Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation
Blood. 2011 Feb 17;117(7):2284-95.
Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC.
PMID: 21183689; PMCID: PMC3062334
Read MoreSphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis
Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):81-5.
Skoura A, Michaud J, Im DS, Thangada S, Xiong Y, Smith JD, Hla T.
PMID: 20947824; PMCID: PMC3013369
Read MoreCell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
J Exp Med. 2010 Jul 5;207(7):1475-83.
Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, Hla T.
PMID: 20584883; PMCID: PMC2901064
Read MoreSin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells
Annarita Di Lorenzo, PhD
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells
Mol Cell. 2010 Aug 13;39(3):433-43.
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.
PMID: 20705244; PMCID: PMC2957800
Read MoreTelmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice
Annarita Di Lorenzo, PhD
Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice
Lab Invest. 2010 Nov;90(11):1573-81.
Krieger MH, Di Lorenzo A, Teutsch C, Kauser K, Sessa WC.
PMID: 20585312; PMCID: PMC3248785
Read MoreCCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations
Annarita Di Lorenzo, PhD
CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations
J Clin Invest. 2010 Aug;120(8):2795-804.
Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML.
PMID: 20592472; PMCID: PMC2912181
Read MoreMatrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: Evidence for the role of TNF-∝ and cyclooxygenase-2.
Domenick J. Falcone, PhD
Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: Evidence for the role of TNF-∝ and cyclooxygenase-2.
J Immunol. 2009 Dec 15;183(12):8119-27.
Steenport M, Khan KM, Du B, Barnhard SE, Dannenberg AJ, Falcone DJ.
PMID: 19923455; PMCID: PMC3621723
Read MoreEssential role of the RNA-binding protein HuR in progenitor cell survival in mice
Essential role of the RNA-binding protein HuR in progenitor cell survival in mice
J Clin Invest. 2009 Dec;119(12):3530-43.
Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C, Furneaux H, Hla T.
PMID: 19884656; PMCID: PMC2786787
Read MoreHydrogen sulphide is involved in testosterone vascular effect
Annarita Di Lorenzo, PhD
Hydrogen sulphide is involved in testosterone vascular effect
Eur Urol. 2009 Aug;56(2):378-83.
Bucci M, Mirone V, Di Lorenzo A, Vellecco V, Roviezzo F, Brancaleone V, Ciro I, Cirino G.
PMID: 18511180
Read MoreReticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
Annarita Di Lorenzo, PhD
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17511-6.
Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC.
PMID: 19805174; PMCID: PMC2762666
Read MoreAbsence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis
Annarita Di Lorenzo, PhD
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis
Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2033-40.
Fernández-Hernando C, József L, Jenkins D, Di Lorenzo A, Sessa WC.
PMID: 19762778; PMCID: PMC2796372
Read MoreAkt1 is critical for acute inflammation and histamine-mediated vascular leakage
Annarita Di Lorenzo, PhD
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14552-7.
Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC.
PMID: 19622728; PMCID: PMC2732859
Read MoreThe Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo
Annarita Di Lorenzo, PhD
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo
Sci Signal. 2009 Aug 4;2(82):ra41.
Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC.
PMID: 19654415
Read MoreVascular endothelium as a contributor of plasma sphingosine 1-phosphate
Vascular endothelium as a contributor of plasma sphingosine 1-phosphate
Circ Res. 2008 Mar 28;102(6):669-76.
Venkataraman K, Lee YM, Michaud J, Thangada S, Ai Y, Bonkovsky HL, Parikh NS, Habrukowich C, Hla T.
PMID: 18258856; PMCID: PMC2659392
Read MoreTobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: Evidence for an EGFR-dependent mechanism
Domenick J. Falcone, PhD
Tobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: Evidence for an EGFR-dependent mechanism
Cancer Res. 2007 Sep 15;67(18):8966-72.
Du B, Leung H, Khan KM, Miller CG, Subbaramaiah K, Falcone DJ, Dannenberg AJ.
PMID: 17875740
Read MoreSphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness
Annarita Di Lorenzo, PhD
Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness
Am J Respir Cell Mol Biol. 2007 Jun;36(6):757-62.
Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G.
PMID: 17322125.
Read MoreTargeting PGE2 receptors as an alternative strategy to block COX-2-dependent extracellular matrix-induced MMP-9 expression by macrophages
Domenick J. Falcone, PhD
Targeting PGE2 receptors as an alternative strategy to block COX-2-dependent extracellular matrix-induced MMP-9 expression by macrophages
J Biol Chem. 2006 Feb 10;281(6):3321-8.
Pavlovic S, Du B, Sakamoto K, Khan KM, Natarajan C, Breyer RM, Dannenberg AJ, Falcone DJ.
PMID: 16338931
Read MoreExtracellular matrix induced cyclooxygenase-2 regulates macrophage proteinase expression
Domenick J. Falcone, PhD
Extracellular matrix induced cyclooxygenase-2 regulates macrophage proteinase expression
J Biol Chem. 2004 May 21;279(21):22039-46.
Khan KM, Howe LR, Falcone DJ.
PMID: 15024003
Read MoreAnnexin II mediates plasminogen-dependent matrix invasion by human monocytes: Enhanced expression by macrophages
Domenick J. Falcone, PhD
Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: Enhanced expression by macrophages
Blood. 2004 Jan 1;103(1):317-24.
Brownstein C, Deora AB, Jacovina AT, Weintraub R, Gertler M, Khan KM, Falcone DJ, Hajjar KA.
PMID: 14504107
Read MoreExposure of cryptic domains in the alpha1-chain of laminin-1 by elastase stimulates macrophages urokinase and MMP-9 expression
Domenick J. Falcone, PhD
Exposure of cryptic domains in the alpha1-chain of laminin-1 by elastase stimulates macrophages urokinase and MMP-9 expression
J Biol Chem. 2002 Apr 19;277(16):13778-86.
Faisal Khan KM, Laurie GW, McCaffrey TA, Falcone DJ.
PMID: 11827968
Read MoreMyocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload
Domenick J. Falcone, PhD
Myocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload
Circulation. 2002 Apr 16;105(15):1837-42.
Borer JS, Truter S, Herrold EM, Falcone DJ, Pena M, Carter JN, Dumlao TF, Lee JA, Supino PG.
PMID: 11956128
Read MoreNerve growth factor activation of erk-1 and erk-2 induces matrix metalloproteinase expression in vascular smooth muscle cells.
Domenick J. Falcone, PhD
Nerve growth factor activation of erk-1 and erk-2 induces matrix metalloproteinase expression in vascular smooth muscle cells.
J Biol Chem. 2002 Jan 18;277(3):2353-9.
Khan KM, Falcone DJ, Kraemer
PMID: 11698409
Read MorePlasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II
Domenick J. Falcone, PhD
Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II
Blood. 2001 Feb 1;97(3):777-84.
Falcone DJ, Borth W, Khan KM, Hajjar KA.
PMID: 11157497
Read MoreSelective activation of MAPKerk1/2 by laminin-1 peptide alpha1:Ser2091-Arg2108 regulates macrophage degradative phenotype
Domenick J. Falcone, PhD
Selective activation of MAPKerk1/2 by laminin-1 peptide alpha1:Ser2091-Arg2108 regulates macrophage degradative phenotype
J Biol Chem. 2000 Feb 11;275(6):4492-8.
Khan KM, Falcone DJ.
PMID: 10660623
Read MoreMacrophage formation of angiostatin during inflammation: A byproduct of the activation of plasminogen. J
Domenick J. Falcone, PhD
Macrophage formation of angiostatin during inflammation: A byproduct of the activation of plasminogen. J
J Biol Chem. 1998 Nov 20;273(47):31480-5.
Falcone DJ, Khan KM, Layne T, Fernandes L.
PMID: 9813061
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