Vascular and Sphingolipid Biology

Dr. Di Lorenzo’s laboratory is interested in two major area of research: one is to define the molecular mechanisms by which endothelial nitric oxide synthase (eNOS)-derived NO controls the endothelial barrier functions to the passage of plasma molecules and inflammatory cells.Another area of research focuses on the role of Nogo-B, belonging to the Reticulon-4 family of proteins expressed in the ER, in vascular function regulation and in cardiac hypertrophy development.

Active Projects

To study the role of eNOS in vascular permeability and inflammatory cell recruitment to the site of inflammation.
To investigate the role of Nogo-B in vascular function and cardiac hypertrophy.

Active Grants

Endothelial sphingolipid synthesis and tissue inflammatory response
PI: Dr. Annarita Di Lorenzo, PhD
National Institutes of Health (NIH)
Endothelial-derived Sphingolipids in Coronary Atherosclerosis
PI: Annarita Di Lorenzo, PhD
Harold S. Geneen Charitable Trust Awards Program for Coronary Heart Disease Research
Role of Nitric Oxide (NO) in Regulating VE-Cadherin Biological Functions
PI: Annarita Di Lorenzo, PhD
American Heart Association (AHA)

Selected Publications

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Sphingolipids: Fats That Protect The Heart

Annarita Di Lorenzo, PhD

Sphingolipids: Fats That Protect The Heart

Scientia. Sep 13, 2017
Di Lorenzo A.
http://www.scientia.global/dr-annarita-di-lorenzo-sphingolipids-fats-protect-heart/

SciPod. October 2017
Di Lorenzo A.
http://www.scipod.global/sphingolipids-fats-that-protect-the-heart-dr-annarita-di-lorenzo-cornell-university/

HIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis

Annarita Di Lorenzo, PhD

HIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis

Hypertension. 2013 Sep;62(3):634-40.

Huang Y, Di Lorenzo A, Jiang W, Cantalupo A, Sessa WC, Giordano FJ.

PMID: 23918749

Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.

Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.

J Biol Chem. 2013 Feb 15;288(7):4908-21.

Chang SH, Lu YC, Li X, Hsieh WY, Xiong Y, Ghosh M, Evans T, Elemento O, Hla T.

PMID: 23223443; PMCID: PMC3576095

Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.

Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.

J Biol Chem. 2013 Jan 25;288(4):2143-56.

Mendelson K, Zygmunt T, Torres-Vázquez J, Evans T, Hla T.

PMID: 23229546

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.

Dev Cell. 2012 Sep 11;23(3):600-10.

Jung B, Obinata H, Galvani S, Mendelson K, Ding BS, Skoura A, Kinzel B, Brinkmann V, Rafii S, Evans T, Hla T.

PMID: 22975328; PMCID: PMC3443394

SnapShot: Bioactive lysophospholipids.

SnapShot: Bioactive lysophospholipids.

Cell. 2012 Jan 20;148(1-2):378-378.e2.

Moolenaar WH, Hla T.

PMID: 22265422

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function

Annarita Di Lorenzo, PhD

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17478-83.

Huang Y, Lei L, Liu D, Jovin I, Russell R, Johnson RS, Di Lorenzo A, Giordano FJ.

PMID: 23047702; PMCID: PMC3491491

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8.

Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B.

PMID: 21606363; PMCID: PMC3111292

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice

J Clin Invest. 2011 Jun;121(6):2290-300.

Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, Blaho V, Hwang SI, Han DK, Hla T.

PMID: 21555855

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

Annarita Di Lorenzo, PhD

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

PLoS One. 2011 Apr 22;6(4):e18869.

Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC.

PMID: 21526127

Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation

Annarita Di Lorenzo, PhD

Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation

Blood. 2011 Feb 17;117(7):2284-95.

Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC.

PMID: 21183689; PMCID: PMC3062334

Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis

Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis

Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):81-5.

Skoura A, Michaud J, Im DS, Thangada S, Xiong Y, Smith JD, Hla T.

PMID: 20947824; PMCID: PMC3013369

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics

J Exp Med. 2010 Jul 5;207(7):1475-83.

Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, Hla T.

PMID: 20584883; PMCID: PMC2901064

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells

Annarita Di Lorenzo, PhD

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells

Mol Cell. 2010 Aug 13;39(3):433-43.

Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.

PMID: 20705244; PMCID: PMC2957800

Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice

Annarita Di Lorenzo, PhD

Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice

Lab Invest. 2010 Nov;90(11):1573-81.

Krieger MH, Di Lorenzo A, Teutsch C, Kauser K, Sessa WC.

PMID: 20585312; PMCID: PMC3248785

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

Annarita Di Lorenzo, PhD

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

J Clin Invest. 2010 Aug;120(8):2795-804.

Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML.

PMID: 20592472; PMCID: PMC2912181

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice

J Clin Invest. 2009 Dec;119(12):3530-43.

Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C, Furneaux H, Hla T.

PMID: 19884656; PMCID: PMC2786787

Hydrogen sulphide is involved in testosterone vascular effect

Annarita Di Lorenzo, PhD

Hydrogen sulphide is involved in testosterone vascular effect

Eur Urol. 2009 Aug;56(2):378-83.

Bucci M, Mirone V, Di Lorenzo A, Vellecco V, Roviezzo F, Brancaleone V, Ciro I, Cirino G.

PMID: 18511180

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair

Annarita Di Lorenzo, PhD

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair

Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17511-6.

Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC.

PMID: 19805174; PMCID: PMC2762666

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis

Annarita Di Lorenzo, PhD

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis

Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2033-40.

Fernández-Hernando C, József L, Jenkins D, Di Lorenzo A, Sessa WC.

PMID: 19762778; PMCID: PMC2796372

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

Annarita Di Lorenzo, PhD

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14552-7.

Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC.

PMID: 19622728; PMCID: PMC2732859

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo

Annarita Di Lorenzo, PhD

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo

Sci Signal. 2009 Aug 4;2(82):ra41.

Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC.

PMID: 19654415

Vascular endothelium as a contributor of plasma sphingosine 1-phosphate

Vascular endothelium as a contributor of plasma sphingosine 1-phosphate

Circ Res. 2008 Mar 28;102(6):669-76.

Venkataraman K, Lee YM, Michaud J, Thangada S, Ai Y, Bonkovsky HL, Parikh NS, Habrukowich C, Hla T.

PMID: 18258856; PMCID: PMC2659392

Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness

Annarita Di Lorenzo, PhD

Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness

Am J Respir Cell Mol Biol. 2007 Jun;36(6):757-62.

Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G.

PMID: 17322125.

Explore

Active Projects

Active Grants

Selected Publications

Sphingolipids: Fats That Protect The Heart

HIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis

Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.

Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.

SnapShot: Bioactive lysophospholipids.

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation

Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells

Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice

Hydrogen sulphide is involved in testosterone vascular effect

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo

Vascular endothelium as a contributor of plasma sphingosine 1-phosphate

Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness

Faculty

Explore

Vascular and Sphingolipid Biology

Active Projects

Active Grants

Selected Publications

Sphingolipids: Fats That Protect The Heart

HIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis

Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.

Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.

Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development.

SnapShot: Bioactive lysophospholipids.

Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function

Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M

Engagement of S1P₁-degradative mechanisms leads to vascular leak in mice

Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.

Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation

Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis

Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells

Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

Essential role of the RNA-binding protein HuR in progenitor cell survival in mice

Hydrogen sulphide is involved in testosterone vascular effect

Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair

Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage

The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo

Vascular endothelium as a contributor of plasma sphingosine 1-phosphate

Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness

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Faculty