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Dr. Di Lorenzo’s laboratory is interested in two major area of research: one is to define the molecular mechanisms by which endothelial nitric oxide synthase (eNOS)-derived NO controls the endothelial barrier functions to the passage of plasma molecules and inflammatory cells.Another area of research focuses on the role of Nogo-B, belonging to the Reticulon-4 family of proteins expressed in the ER, in vascular function regulation and in cardiac hypertrophy development.
Annarita Di Lorenzo, PhD
Sphingolipids: Fats That Protect The Heart
Scientia. Sep 13, 2017
Di Lorenzo A.
http://www.scientia.global/dr-annarita-di-lorenzo-sphingolipids-fats-protect-heart/
SciPod. October 2017
Di Lorenzo A.
http://www.scipod.global/sphingolipids-fats-that-protect-the-heart-dr-annarita-di-lorenzo-cornell-university/
Annarita Di Lorenzo, PhD
HIF-1α in vascular smooth muscle regulates blood pressure homeostasis through a PPARγ-angiotensin I receptor type 1 axis
Hypertension. 2013 Sep;62(3):634-40.
Huang Y, Di Lorenzo A, Jiang W, Cantalupo A, Sessa WC, Giordano FJ.
PMID: 23918749
Read MoreAntagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis.
J Biol Chem. 2013 Feb 15;288(7):4908-21.
Chang SH, Lu YC, Li X, Hsieh WY, Xiong Y, Ghosh M, Evans T, Elemento O, Hla T.
PMID: 23223443; PMCID: PMC3576095
Read MoreSphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning.
J Biol Chem. 2013 Jan 25;288(4):2143-56.
Mendelson K, Zygmunt T, Torres-Vázquez J, Evans T, Hla T.
PMID: 23229546
Read MoreFlow-regulated endothelial S1P receptor-1 signaling sustains vascular development.
Dev Cell. 2012 Sep 11;23(3):600-10.
Jung B, Obinata H, Galvani S, Mendelson K, Ding BS, Skoura A, Kinzel B, Brinkmann V, Rafii S, Evans T, Hla T.
PMID: 22975328; PMCID: PMC3443394
Read MoreSnapShot: Bioactive lysophospholipids.
Cell. 2012 Jan 20;148(1-2):378-378.e2.
Moolenaar WH, Hla T.
PMID: 22265422
Read MoreAnnarita Di Lorenzo, PhD
Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17478-83.
Huang Y, Lei L, Liu D, Jovin I, Russell R, Johnson RS, Di Lorenzo A, Giordano FJ.
PMID: 23047702; PMCID: PMC3491491
Read MoreEndothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9613-8.
Christoffersen C, Obinata H, Kumaraswamy SB, Galvani S, Ahnström J, Sevvana M, Egerer-Sieber C, Muller YA, Hla T, Nielsen LB, Dahlbäck B.
PMID: 21606363; PMCID: PMC3111292
Read MoreEngagement of S1P₁-degradative mechanisms leads to vascular leak in mice
J Clin Invest. 2011 Jun;121(6):2290-300.
Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, Blaho V, Hwang SI, Han DK, Hla T.
PMID: 21555855
Read MoreAnnarita Di Lorenzo, PhD
Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function.
PLoS One. 2011 Apr 22;6(4):e18869.
Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC.
PMID: 21526127
Read MoreAnnarita Di Lorenzo, PhD
Endothelial Reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation
Blood. 2011 Feb 17;117(7):2284-95.
Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC.
PMID: 21183689; PMCID: PMC3062334
Read MoreSphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):81-5.
Skoura A, Michaud J, Im DS, Thangada S, Xiong Y, Smith JD, Hla T.
PMID: 20947824; PMCID: PMC3013369
Read MoreCell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics
J Exp Med. 2010 Jul 5;207(7):1475-83.
Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, Hla T.
PMID: 20584883; PMCID: PMC2901064
Read MoreAnnarita Di Lorenzo, PhD
Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells
Mol Cell. 2010 Aug 13;39(3):433-43.
Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.
PMID: 20705244; PMCID: PMC2957800
Read MoreAnnarita Di Lorenzo, PhD
Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice
Lab Invest. 2010 Nov;90(11):1573-81.
Krieger MH, Di Lorenzo A, Teutsch C, Kauser K, Sessa WC.
PMID: 20585312; PMCID: PMC3248785
Read MoreAnnarita Di Lorenzo, PhD
CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations
J Clin Invest. 2010 Aug;120(8):2795-804.
Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML.
PMID: 20592472; PMCID: PMC2912181
Read MoreEssential role of the RNA-binding protein HuR in progenitor cell survival in mice
J Clin Invest. 2009 Dec;119(12):3530-43.
Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, Hemmes A, Ristimaki A, Guo C, Furneaux H, Hla T.
PMID: 19884656; PMCID: PMC2786787
Read MoreAnnarita Di Lorenzo, PhD
Hydrogen sulphide is involved in testosterone vascular effect
Eur Urol. 2009 Aug;56(2):378-83.
Bucci M, Mirone V, Di Lorenzo A, Vellecco V, Roviezzo F, Brancaleone V, Ciro I, Cirino G.
PMID: 18511180
Read MoreAnnarita Di Lorenzo, PhD
Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17511-6.
Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC.
PMID: 19805174; PMCID: PMC2762666
Read MoreAnnarita Di Lorenzo, PhD
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis
Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2033-40.
Fernández-Hernando C, József L, Jenkins D, Di Lorenzo A, Sessa WC.
PMID: 19762778; PMCID: PMC2796372
Read MoreAnnarita Di Lorenzo, PhD
Akt1 is critical for acute inflammation and histamine-mediated vascular leakage
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14552-7.
Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC.
PMID: 19622728; PMCID: PMC2732859
Read MoreAnnarita Di Lorenzo, PhD
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo
Sci Signal. 2009 Aug 4;2(82):ra41.
Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC.
PMID: 19654415
Read MoreVascular endothelium as a contributor of plasma sphingosine 1-phosphate
Circ Res. 2008 Mar 28;102(6):669-76.
Venkataraman K, Lee YM, Michaud J, Thangada S, Ai Y, Bonkovsky HL, Parikh NS, Habrukowich C, Hla T.
PMID: 18258856; PMCID: PMC2659392
Read MoreAnnarita Di Lorenzo, PhD
Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness
Am J Respir Cell Mol Biol. 2007 Jun;36(6):757-62.
Roviezzo F, Di Lorenzo A, Bucci M, Brancaleone V, Vellecco V, De Nardo M, Orlotti D, De Palma R, Rossi F, D'Agostino B, Cirino G.
PMID: 17322125.
Read More