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Pengbo Zhou, PhD, Principal Investigator
Selective degradation of specific cellular proteins by the ubiquitin-proteasome pathway (UPP) is essential for a variety of vital cellular functions. We are interested in aspects of the UPP pertaining to physiological and pathological conditions, including the onset and maintenance of tumor growth as well as drug susceptibility.
Active Projects
- The role of CRL4 ubiquitin ligase in tumorigenesis and chemotherapy resistance.
- Ubiquitination and degradation of proteins involved in normal and malignant hematopoiesis.
- CRL4 function in embryonic development, reproduction, and neurological disease
Active Grants
- Harnessing the CRL4 ubiquitin ligase for antagonizing colorectal carcinogenesis
PI: Pengbo Zhou, PhD
National Institutes of Health (NIH) Research Grant - Validation of CUL4B mAbs
PI: Pengbo Zhou, PhD
Cullinogen, Inc Sponsored Research Agreement - Ubiquitin Ligase Inhibitors as Protective Agents Against Cancer
PI: Pengbo Zhou, PhD
The Daedalus Fund For Innovation Research Grant - Identification of small molecule inhibitors of the CRL4 ubiquitin ligase
PI: Pengbo Zhou, PhD
Sanofi-Aventis - Regulation of Nucleotide Excision Repair by Proteolysis
PI: Pengbo Zhou, PhD
National Institutes of Health (NIH) - Tumorigenic Role of the CUL4A Ubiquitin Ligas
PI: Pengbo Zhou, PhD
National Institutes of Health (NIH)
Selected Publications
CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity
Pengbo Zhou, PhD
CDK4/6 Inhibitor PD 0332991 Sensitizes Acute Myeloid Leukemia to Cytarabine-Mediated Cytotoxicity
Cancer Res. 2015 May 1;75(9):1838-45.
Yang C, Boyson CA, Di Liberto M, Huang X, Hannah J, Dorn DC, Moore MA, Chen-Kiang S, Zhou P.
PMID: 25744718; PMCID: PMC4417369
Read MoreEngineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases.
Pengbo Zhou, PhD
Engineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases.
Oncogene. 2014 Feb 20;33(8):986-95.
Kong F, Zhang J, Li Y, Hao X, Ren X, Li H, Zhou P.
PMID: 23416973; PMCID: PMC3930622
Read MoreAxl receptor tyrosine kinase expression in breast cancer
Pengbo Zhou, PhD
Axl receptor tyrosine kinase expression in breast cancer
J Clin Pathol. 2014 Aug;67(8):690-6.
D'Alfonso TM, Hannah J, Chen Z, Liu Y, Zhou P, Shin SJ.
PMID: 24904064; PMCID: PMC4549806
Read MoreMerlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
Pengbo Zhou, PhD
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
Cancer Cell. 2014 Jul 14;26(1):48-60.
Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H, Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P, Karajannis MA, Giancotti FG.
PMID: 25026211; PMCID: PMC4126592
Read MoreThe transcription factor TFII-I promotes DNA translesion synthesis and genomic stability.
Pengbo Zhou, PhD
The transcription factor TFII-I promotes DNA translesion synthesis and genomic stability.
PLoS Genet. 2014 Jun 12;10(6):e1004419.
Fattah FJ, Hara K, Fattah KR, Yang C, Wu N, Warrington R, Chen DJ, Zhou P, Boothman DA, Yu H.
PMID: 24922507; PMCID: PMC4055408
Read MoreEngineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases
Pengbo Zhou, PhD
Engineering a single ubiquitin ligase for the selective degradation of all activated ErbB receptor tyrosine kinases
Oncogene. 2014 Feb 20;33(8):986-95.
Kong F, Zhang J, Li Y, Hao X, Ren X, Li H, Zhou P.
PMID: 23416973; PMCID: PMC3930622
Read MoreThe CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies
Pengbo Zhou, PhD
The CUL4A ubiquitin ligase is a potential therapeutic target in skin cancer and other malignancies
Cancer. 2013 Sep;32(9):478-82.
Hannah J, Zhou PB. Chin J.
PMID: 23845142; PMCID: PMC3845565
Read MoreImproved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4.
Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4.
Blood. 2013 May 16;121(20):4082-9.
Lee J, Shieh JH, Zhang J, Liu L, Zhang Y, Eom JY, Morrone G, Moore MA, Zhou P.
PMID: 23520338
Read MoreProstate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
Pengbo Zhou, PhD
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover
Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6997-7002.
Geng C, He B, Xu L, Barbieri CE, Eedunuri VK, Chew SA, Zimmermann M, Bond R, Shou J, Li C, Blattner M, Lonard DM, Demichelis F, Coarfa C, Rubin MA, Zhou P, O'Malley BW, Mitsiades N.
PMID: 23559371; PMCID: PMC3637757
Read MoreEssential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.
Pengbo Zhou, PhD
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.
Cell Res. 2012 Aug;22(8):1258-69.
Liu L, Yin Y, Li Y, Prevedel L, Lacy EH, Ma L, Zhou P.
PMID: 22453236
Read MoreEssential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.
Pengbo Zhou, PhD
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.
Cell Res. 2012 Aug;22(8):1258-69.
Liu L, Yin Y, Li Y, Prevedel L, Lacy EH, Ma L, Zhou P.
PMID: 22453236
Read MorePathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease
Pengbo Zhou, PhD
Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease
Front Oncol. 2012 Mar 6;2:21.
Lee J, Zhou P.
PMID: 22649780; PMCID: PMC3355902
Read MoreMaximizing target protein ablation by integration of RNAi and protein knockout
Pengbo Zhou, PhD
Maximizing target protein ablation by integration of RNAi and protein knockout
Cell Res. 2011 Jul;21(7):1152-4.
Hannah J, Zhou P.
PMID: 21606956; PMCID: PMC3129447
Read MoreCullins and cancer
Pengbo Zhou, PhD
Cullins and cancer
Genes Cancer. 2010 Jul;1(7):690-9.
Lee J, Zhou P.
PMID: 21127736; PMCID: PMC2994581
Read MoreMerlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
Pengbo Zhou, PhD
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
Cell. 2010 Feb 19;140(4):477-90.
Li W, You L, Cooper J, Schiavon G, Pepe-Caprio A, Zhou L, Ishii R, Giovannini M, Hanemann CO, Long SB, Erdjument-Bromage H, Zhou P, Tempst P, Giancotti FG.
PMID: 20178741; PMCID:PMC2828953
Read MoreSETting the clock for histone H4 monomethylation
Pengbo Zhou, PhD
SETting the clock for histone H4 monomethylation
Mol Cell. 2010 Nov 12;40(3):345-6.
Lee J, Zhou P.
PMID: 21070959; PMCID: PMC3003296
Read MoreNavigating the nucleotide excision repair threshold
Navigating the nucleotide excision repair threshold
J Cell Physiol. 2010 Sep;224(3):585-9.
Liu L, Lee J, Zhou P.
PMID: 20458729; PMCID: PMC2897951
Read MoreCUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.
CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.
Mol Cell. 2009 May 14;34(4):451-60.
Liu L, Lee S, Zhang J, Peters SB, Hannah J, Zhang Y, Yin Y, Koff A, Ma L, Zhou P.
PMID: 19481525; PMCID: PMC2722740
Read MoreRegulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
Pengbo Zhou, PhD
Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases
DNA Repair (Amst). 2009 Apr 5;8(4):536-43.
Hannah J, Zhou P.
PMID: 19231300; PMCID: PMC2858918
Read MoreDCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
Pengbo Zhou, PhD
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase
Mol Cell. 2007 Jun 22;26(6):775-80.
Lee J, Zhou P.
PMID: 17588513
Read MoreA kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins.
Pengbo Zhou, PhD
A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins.
Mol Cell. 2006 May 19;22(4):489-99.
Chen X, Zhang J, Lee J, Lin PS, Ford JM, Zheng N, Zhou P.
PMID: 16713579
Read MoreREGgamma: a shortcut to destruction.
Pengbo Zhou, PhD
REGgamma: a shortcut to destruction.
Cell. 2006 Jan 27;124(2):256-7.
Zhou P.
PMID: 16439199
Read MoreStructure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
Pengbo Zhou, PhD
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.
Cell. 2006 Jan 13;124(1):105-17.
Li T, Chen X, Garbutt KC, Zhou P, Zheng N.
PMID: 16413485
Read MoreEctopic targeting of substrates to the ubiquitin pathway
Pengbo Zhou, PhD
Ectopic targeting of substrates to the ubiquitin pathway
Methods Enzymol. 2005;399:823-33.
Zhang J, Zhou P.
PMID: 16338397
Read MoreTargeted protein degradation
Pengbo Zhou, PhD
Targeted protein degradation
Curr Opin Chem Biol. 2005 Feb;9(1):51-5.
Zhou P.
PMID: 15701453
Read MoreTransient in utero knockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouse.
Pengbo Zhou, PhD
Transient in utero knockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouse.
BMC Dev Biol. 2004 Apr 16;4:4.
Cohen JC, Scott DK, Miller J, Zhang J, Zhou P, Larson JE.
PMID: 15090077; PMCID: PMC419337
Read MoreA protein knockdown strategy to study the function of beta-catenin in tumorigenesis.
Pengbo Zhou, PhD
A protein knockdown strategy to study the function of beta-catenin in tumorigenesis.
BMC Mol Biol. 2003 Sep 29;4:10.
Cong F, Zhang J, Pao W, Zhou P, Varmus H.
PMID: 14516475; PMCID: PMC222962
Read MoreExploring the functional complexity of cellular proteins by protein knockout.
Pengbo Zhou, PhD
Exploring the functional complexity of cellular proteins by protein knockout.
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14127-32.
Zhang J, Zheng N, Zhou P.
PMID: 14593203; PMCID: PMC283557
Read MoreCUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.
Pengbo Zhou, PhD
CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.
EMBO J. 2003 Nov 17;22(22):6057-67.
Zhang Y, Morrone G, Zhang J, Chen X, Lu X, Ma L, Moore M, Zhou P.
PMID: 14609952; PMCID: PMC275435
Read More
