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David Rickman, PhD, Principal Investigator
The Oncogenic Transcription Factors in Prostate Cancer laboratory is focused on elucidating the role of oncogenic transcription factors (e.g. ETS family members and N-Myc) in coordinating gene regulation, chromatin 3D architecture and response to chemotherapy in the context of prostate adenocarcinoma and neuroendocrine prostate cancer.
Active Projects
- The role of ERG in mediating taxane resistance.
- The role of N-Myc in driving the neuroendocrine prostate cancer phenotype.
- Development of in vitro and in vivo model systems of oncogenic transcription factor over-expression and other genomic alterations in prostate cancer.
Active Grants
- Identification of Novel Therapeutics for Treatment of N-MYC Driven Castrate Resistant Prostate Cancer
PI: David Rickman, PhD
Tri-Institutional Therapeutics Discovery Institute - Temporal Evolution of N-Myc Signaling and Early Targeting of the Neuroendocrine Phenotype in Prostate Cancer
PI: David Rickman, PhD
United States Department of Defense - Janssen-Challenge Award
Prostate Cancer Foundation
“Targeting and mechanistic insights underlying N-Myc driven Neuroendocrine Prostate Cancer”
The aim of this study is to characterize the driving role of N-Myc and AURKA in neuroendocrine prostate cancer with the ultimate goal of more effectively targeting this tumor subclass by disrupting this complex.
Role: PI - 1R01CA179100-01A1
NIH-National Cancer Institute
“Mechanistic Insights Underlying ERG-induced Taxane Resistance in Castration-Resistant Prostate Cancer”
The aim of this study is to characterize the mechanism underlying ERG-induced taxane resistance in castrate resistant prostate cancer.
Role: PI
Selected Publications
ERG induces taxane resistance in castration-resistant prostate cancer.
David Rickman, PhD
ERG induces taxane resistance in castration-resistant prostate cancer.
Nat Commun. 2014 Nov 25;5:5548.
Galletti G, Matov A, Beltran H, Fontugne J, Miguel Mosquera J, Cheung C, MacDonald TY, Sung M, O'Toole S, Kench JG, Suk Chae S, Kimovski D, Tagawa ST, Nanus DM, Rubin MA, Horvath LG, Giannakakou P, Rickman DS.
PubMed PMID: 25420520; PMCID: PMC4244604
Read MoreCombining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer.
David Rickman, PhD
Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer.
Urol Oncol. 2013 Jul;31(5):566-71.
Salami SS, Schmidt F, Laxman B, Regan MM, Rickman DS, Scherr D, Bueti G, Siddiqui J, Tomlins SA, Wei JT, Chinnaiyan AM, Rubin MA, Sanda MG.
PMID: 21600800
Read MoreOncogenic transcription factors as master regulators of chromatin topology: a new role for ERG in prostate cancer
David Rickman, PhD
Oncogenic transcription factors as master regulators of chromatin topology: a new role for ERG in prostate cancer
Cell Cycle. 2012 Sep 15;11(18):3380-3.
Elemento O, Rubin MA, Rickman DS.
PMID: 22918253; PMCID: PMC3466547
Read MoreOncogene-mediated alterations in chromatin conformation
David Rickman, PhD
Oncogene-mediated alterations in chromatin conformation
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9083-8.
Rickman DS, Soong TD, Moss B, Mosquera JM, Dlabal J, Terry S, MacDonald TY, Tripodi J, Bunting K, Najfeld V, Demichelis F, Melnick AM, Elemento O, Rubin MA.
PMID: 22615383; PMCID: PMC3384175
Read MoreDiscovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing
David Rickman, PhD
Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing
Genome Res. 2011 Jan;21(1):56-67.
Pflueger D, Terry S, Sboner A, Habegger L, Esgueva R, Lin PC, Svensson MA, Kitabayashi N, Moss BJ, MacDonald TY, Cao X, Barrette T, Tewari AK, Chee MS, Chinnaiyan AM, Rickman DS, Demichelis F, Gerstein MB, Rubin MA.
PMID: 21036922; PMCID: PMC3012926
Read MoreERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression
David Rickman, PhD
ERG cooperates with androgen receptor in regulating trefoil factor 3 in prostate cancer disease progression
Neoplasia. 2010 Dec;12(12):1031-40.
Rickman DS, Chen YB, Banerjee S, Pan Y, Yu J, Vuong T, Perner S, Lafargue CJ, Mertz KD, Setlur SR, Sircar K, Chinnaiyan AM, Bismar TA, Rubin MA, Demichelis F.
PMID: 21170267; PMCID: PMC3003138
Read MoreERG rearrangement metastasis patterns in locally advanced prostate cancer
David Rickman, PhD
ERG rearrangement metastasis patterns in locally advanced prostate cancer
Urology. 2010 Apr;75(4):762-7.
Perner S, Svensson MA, Hossain RR, Day JR, Groskopf J, Slaughter RC, Jarleborn AR, Hofer MD, Kuefer R, Demichelis F, Rickman DS, Rubin MA.
PMID: 20018353; PMCID: PMC2850965
Read MoreWNT/beta-catenin pathway activation in Wilms tumors: a unifying mechanism with multiple entries?
David Rickman, PhD
WNT/beta-catenin pathway activation in Wilms tumors: a unifying mechanism with multiple entries?
Genes Chromosomes Cancer. 2009 Sep;48(9):816-27.
Corbin M, de Reyniès A, Rickman DS, Berrebi D, Boccon-Gibod L, Cohen-Gogo S, Fabre M, Jaubert F, Faussillon M, Yilmaz F, Sarnacki S, Landman-Parker J, Patte C, Schleiermacher G, Antignac C, Jeanpierre C.
PMID: 19530245
Read MoreN-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer.
David Rickman, PhD
N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer.
Neoplasia. 2009 Aug;11(8):804-11.
Pflueger D, Rickman DS, Sboner A, Perner S, LaFargue CJ, Svensson MA, Moss BJ, Kitabayashi N, Pan Y, de la Taille A, Kuefer R, Tewari AK, Demichelis F, Chee MS, Gerstein MB, Rubin MA.
PMID: 19649210; PMCID: PMC2713587
Read MoreSLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer.
David Rickman, PhD
SLC45A3-ELK4 is a novel and frequent erythroblast transformation-specific fusion transcript in prostate cancer.
Cancer Res. 2009 Apr 1;69(7):2734-8.
Rickman DS, Pflueger D, Moss B, VanDoren VE, Chen CX, de la Taille A, Kuefer R, Tewari AK, Setlur SR, Demichelis F, Rubin MA.
PMID: 19293179; PMCID: PMC4063441
Read MoreDistinct genomic aberrations associated with ERG rearranged prostate cancer.
David Rickman, PhD
Distinct genomic aberrations associated with ERG rearranged prostate cancer.
Genes Chromosomes Cancer. 2009 Apr;48(4):366-80.
Demichelis F, Setlur SR, Beroukhim R, Perner S, Korbel JO, Lafargue CJ, Pflueger D, Pina C, Hofer MD, Sboner A, Svensson MA, Rickman DS, Urban A, Snyder M, Meyerson M, Lee C, Gerstein MB, Kuefer R, Rubin MA.
PMID: 19156837; PMCID: PMC2674964
Read MoreGene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival
David Rickman, PhD
Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival
J Clin Oncol. 2009 Mar 1;27(7):1108-15.
de Reyniès A, Assié G, Rickman DS, Tissier F, Groussin L, René-Corail F, Dousset B, Bertagna X, Clauser E, Bertherat J.
PMID: 19139432
Read MoreHepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer
David Rickman, PhD
Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer
Cancer Cell. 2008 Dec 9;14(6):471-84.
Cairo S, Armengol C, De Reyniès A, Wei Y, Thomas E, Renard CA, Goga A, Balakrishnan A, Semeraro M, Gresh L, Pontoglio M, Strick-Marchand H, Levillayer F, Nouet Y, Rickman D, Gauthier F, Branchereau S, Brugières L, Laithier V, Bouvier R, Boman F, Basso G, Michiels JF, Hofman P, Arbez-Gindre F, Jouan H, Rousselet-Chapeau MC, Berrebi D, Marcellin L, Plenat F, Zachar D, Joubert M, Selves J, Pasquier D, Bioulac-Sage P, Grotzer M, Childs M, Fabre M, Buendia MA.
PMID: 19061838
Read MorePrediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays
David Rickman, PhD
Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays
Oncogene. 2008 Nov 20;27(51):6607-22.
Rickman DS, Millon R, De Reynies A, Thomas E, Wasylyk C, Muller D, Abecassis J, Wasylyk B.
PMID: 18679425
Read MoreEML4-ALK fusion lung cancer: a rare acquired event
David Rickman, PhD
EML4-ALK fusion lung cancer: a rare acquired event
Neoplasia. 2008 Mar;10(3):298-302.
Perner S, Wagner PL, Demichelis F, Mehra R, Lafargue CJ, Moss BJ, Arbogast S, Soltermann A, Weder W, Giordano TJ, Beer DG, Rickman DS, Chinnaiyan AM, Moch H, Rubin MA.
PMID: 18320074; PMCID: PMC2259458
Read MoreThe gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells.
David Rickman, PhD
The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells.
Blood. 2007 Jun 1;109(11):4952-63.
de Leval L, Rickman DS, Thielen C, Reynies Ad, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P.
PMID: 17284527
Read MorePre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia
David Rickman, PhD
Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia
Blood. 2007 May 1;109(9):3972-81.
dos Santos NR, Rickman DS, de Reynies A, Cormier F, Williame M, Blanchard C, Stern MH, Ghysdael J.
PubMed PMID: 17192390
Read MoreExquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen
David Rickman, PhD
Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen
PLoS Med. 2007 Mar;4(3):e90.
Bertheau P, Turpin E, Rickman DS, Espié M, de Reyniès A, Feugeas JP, Plassa LF, Soliman H, Varna M, de Roquancourt A, Lehmann-Che J, Beuzard Y, Marty M, Misset JL, Janin A, de Thé H.
PMID: 17388661; PMCID: PMC1831731
Read MoreGene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes
David Rickman, PhD
Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes
Blood. 2007 Mar 1;109(5):2156-64.
Lamant L, de Reyniès A, Duplantier MM, Rickman DS, Sabourdy F, Giuriato S, Brugières L, Gaulard P, Espinos E, Delsol G.
PMID: 17077326
Read MoreTranscriptome classification of HCC is related to gene alterations and to new therapeutic targets
David Rickman, PhD
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
Hepatology. 2007 Jan;45(1):42-52
Boyault S, Rickman DS, de Reyniès A, Balabaud C, Rebouissou S, Jeannot E, Hérault A, Saric J, Belghiti J, Franco D, Bioulac-Sage P, Laurent-Puig P, Zucman-Rossi J.
PubMed PMID: 17187432
Read MoreApc tumor suppressor gene is the "zonation-keeper" of mouse liver
David Rickman, PhD
Apc tumor suppressor gene is the "zonation-keeper" of mouse liver
Dev Cell. 2006 Jun;10(6):759-70.
Benhamouche S, Decaens T, Godard C, Chambrey R, Rickman DS, Moinard C, Vasseur-Cognet M, Kuo CJ, Kahn A, Perret C, Colnot S.
PubMed PMID: 16740478
Read MoreDistinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis
David Rickman, PhD
Distinctive molecular profiles of high-grade and low-grade gliomas based on oligonucleotide microarray analysis
Cancer Res. 2001 Sep 15;61(18):6885-91.
Rickman DS, Bobek MP, Misek DE, Kuick R, Blaivas M, Kurnit DM, Taylor J, Hanash SM.
PubMed PMID: 11559565
Read MoreThe gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas
David Rickman, PhD
The gene for the axonal cell adhesion molecule TAX-1 is amplified and aberrantly expressed in malignant gliomas
Cancer Res. 2001 Mar 1;61(5):2162-8.
Rickman DS, Tyagi R, Zhu XX, Bobek MP, Song S, Blaivas M, Misek DE, Israel MA, Kurnit DM, Ross DA, Kish PE, Hanash SM.
PubMed PMID: 11280781
Read More