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Ji-Hye Paik, PhD, Principal Investigator
We aim to understand the homeostatic mechanism of adult stem cells that is intimately linked to aging and cancer, with a hope to apply these principles for regenerative and cancer therapeutics. We employ multi-disciplinary approaches including mouse models, cell and molecular biology, metabolomics and genomics. We currently pursue PI3K-Akt-FoxO-mediated homeostatic pathway and ZNF365-dependent genomic stability.
Active Projects
- Mechanism of Oxidative Brain Aging
- Functional role of ZNF365 in breast cancer pathogenesis
Active Grants
- The Mechanisms Underlying How Oxidative Stress Influences Neural Stem Cell Fate.
The goal is to determine the key mechanisms and cellular consequences of oxidative stress in NPCs.
PI: Jihye Paik, PhD
NIH/NIA - Targeting Methylation Potential of Therapy Resistant Gliomas
PI: Jihye Paik, PhD
Irma T. Hirschl Trust - Irma T. Hirschl Career Scientist Award - Molecular Mechanism of FOXO-dependent NSC fate decision in aging brain
PI: Jihye Paik, PhD
Ellison Medical Foundation - Function of FoxO in EGFR-targeted gliomas
PI: Jihye Paik, PhD
Sidney Kimmel Cancer Foundation
Selected Publications
Functional regulation of FoxO1 in neural stem cell differentiation
Ji-Hye Paik, PhD
Functional regulation of FoxO1 in neural stem cell differentiation
Cell Death Differ. 2015 Oct 16. [Epub ahead of print]
Kim DY, Hwang I, Muller FL, Paik JH.
PMID: 26470727
Read MoreForkhead box O transcription factors in chondrocytes regulate endochondral bone formation.
Ji-Hye Paik, PhD
Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation.
J Steroid Biochem Mol Biol. 2015 Jul 29. [Epub ahead of print]
Eelen G, Verlinden L, Maes C, Beullens I, Gysemans C, Paik JH, DePinho RA, Bouillon R, Carmeliet G, Verstuyf A.
PMID: 26232637
Read MoreDevelopment of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Ji-Hye Paik, PhD
Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Cancer Res. 2015 May 15;75(10):2109-19.
Klingler S, Guo B, Yao J, Yan H, Zhang L, Vaseva AV, Chen S, Canoll P, Horner JW, Wang YA, Paik JH, Ying H, Zheng H.
PMID: 25808866; PMCID: PMC4433602
Read MoreFoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization
Ji-Hye Paik, PhD
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization
Nat Commun. 2015 May 12;6:7079.
O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG.
PMID: 25963540
Read MoreRegulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy
Ji-Hye Paik, PhD
Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy
Nat Commun. 2015 Apr 10;6:6670.
Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, Seydel A, Zhao J, Abraham R, Goldberg AL, Blaauw B, DePinho RA, Sandri M.
PMID: 25858807; PMCID: PMC4403316
Read MoreMetabolic circuits in neural stem cells.
Ji-Hye Paik, PhD
Metabolic circuits in neural stem cells.
Cell Mol Life Sci. 2014 Nov;71(21):4221-41.
Kim DY, Rhee I, Paik J.
PMID: 25037158
Read MoreProlyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Ji-Hye Paik, PhD
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Genes Dev. 2014 Jul 1;28(13):1429-44.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q.
PMID: 24990963; PMCID: PMC4083087
Read MoremTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.
Ji-Hye Paik, PhD
mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases.
Sci Signal. 2014 Feb 25;7(314):ra18.
Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A, Sugiarto S, Garner M, Paik J, DePinho RA, Goldman D, Guan KL, Shrager JB.
PMID: 24570486
Read MoreFoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.
Ji-Hye Paik, PhD
FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells.
EMBO J. 2013 Oct 2;32(19):2589-602.
Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC, Paik JH.
PMID: 24013118; PMCID: PMC3791369.
Read MoreZNF365 promotes stalled replication forks recovery to maintain genome stability.
Ji-Hye Paik, PhD
ZNF365 promotes stalled replication forks recovery to maintain genome stability.
Cell Cycle. 2013 Sep 1;12(17):2817-28.
Zhang Y, Park E, Kim CS, Paik JH.
PMID: 23966166
Read MoreZNF365 promotes stability of fragile sites and telomeres.
Ji-Hye Paik, PhD
ZNF365 promotes stability of fragile sites and telomeres.
Cancer Discov. 2013 Jul;3(7):798-811.
Zhang Y, Shin SJ, Liu D, Ivanova E, Foerster F, Ying H, Zheng H, Xiao Y, Chen Z, Protopopov A, Depinho RA, Paik JH.
PMID: 23776040; PMCID: PMC3710545.
Read MoreFoxOs in neural stem cell fate decision
Ji-Hye Paik, PhD
FoxOs in neural stem cell fate decision
Arch Biochem Biophys. 2013 Jun;534(1-2):55-63.
Ro SH, Liu D, Yeo H, Paik JH.
PMID: 22902436
Read MoreOncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Ji-Hye Paik, PhD
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Cell. 2012 Apr 27;149(3):656-70.
Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA.
PMID: 22541435; PMCID: PMC3472002
Read MoreSTAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA
Ji-Hye Paik, PhD
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA
Genes Dev. 2012 Jul 1;26(13):1459-72.
Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA.
PMID: 22751500; PMCID: PMC3403014
Read MoreTelomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Ji-Hye Paik, PhD
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Nature. 2011 Jan 6;469(7328):102-6.
Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA.
PMID: 21113150; PMCID: PMC3057569
Read MorePLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas
Ji-Hye Paik, PhD
PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas
Cancer Cell. 2010 May 18;17(5):497-509.
Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA.
PMID: 20478531; PMCID: PMC2900858
Read MorePI3 kinase signals BCR-dependent mature B cell survival
Ji-Hye Paik, PhD
PI3 kinase signals BCR-dependent mature B cell survival
Cell. 2009 Oct 30;139(3):573-86.
Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K.
PMID: 19879843; PMCID: PMC2787092
Read MoreFoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
Ji-Hye Paik, PhD
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
Cell Stem Cell. 2009 Nov 6;5(5):540-53.
Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA.
PMID: 19896444; PMCID: PMC3285492
Read MoreCodependent activators direct myoblast-specific MyoD transcription
Ji-Hye Paik, PhD
Codependent activators direct myoblast-specific MyoD transcription
Dev Cell. 2008 Oct;15(4):534-46.
Hu P, Geles KG, Paik JH, DePinho RA, Tjian R.
PMID: 18854138; PMCID: PMC2614327
Read MoreFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
Ji-Hye Paik, PhD
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
Cell. 2007 Jan 26;128(2):309-23.
Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA.
PMID: 17254969; PMCID: PMC1855089
Read MoreFoxOs in the maintenance of vascular homeostasis
Ji-Hye Paik, PhD
FoxOs in the maintenance of vascular homeostasis
Biochem Soc Trans. 2006 Nov;34(Pt 5):731-4.
Paik JH.
PubMed PMID: 17052184
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