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The Nam Lab seeks to decipher the genotype-to-phenotype relationships in neoplastic blood development. In particular, we recognize that somatic mutations alone do not fully explain cancer phenotypes and seek to define the non-genetic modulators of disease states. For example, our work in myeloproliferative neoplasms demonstrated that the transcriptional impact of somatic mutations varies as a function of cell identity. Thus, our goal is to understand how non-genetic modifiers of somatic mutation impact (such as cell identity, epigenetics and microenvironment) may dictate disease states and patient outcomes. Our lab focuses on developing single-cell multi-omics technologies and computational algorithms to address these questions directly in human hematopoiesis. In this way, we reveal fundamental concepts of tumorigenesis and evolution, as well as identify specific therapeutic targets for translational impact.
Anna (Seung Ha) Nam, MD
Somatic mutations and cell identity linked by Genotyping of Transcriptomes
Nature. 2019 Jul;571(7765):355-360.
Nam AS, Kim KT, Chaligne R, Izzo F, Ang C, Taylor J, Myers RM, Abu-Zeinah G, Brand R, Omans ND, Alonso A, Sheridan C, Mariani M, Dai X, Harrington E, Pastore A, Cubillos-Ruiz JR, Tam W, Hoffman R, Rabadan R, Scandura JM, Abdel-Wahab O, Smibert P, Landau DA.
PMID: 31270458; PMCID: PMC6782071
Read MoreAnna (Seung Ha) Nam, MD
Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics
Nat Rev Genet. 2020 Aug 17. Review Article.
Nam AS, Chaligne R, Landau DA.
Read MoreAnna (Seung Ha) Nam, MD
DNA methylation disruption reshapes the hematopoietic differentiation landscape
Nat Genet. 2020 Apr;52(4):378-387.
Izzo F, Lee SC, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA.
PMID: 32203468; PMCID: PMC7216752
Read MoreAnna (Seung Ha) Nam, MD
Exploring tumor clonal evolution in bone marrow of patients with diffuse large B-cell lymphoma by deep IGH sequencing and its potential relevance in relapse
Blood Cancer J. 2019 Aug 21;9(9):69.
Ma J, Redmond D, Miyaguchi A, Nam AS, Nie K, Mathew S, Elemento O, Tam W.
PMID: 31434873; PMCID: PMC6704167
Read MoreAnna (Seung Ha) Nam, MD
Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum
PLoS Biol. 2018 Aug 7;16(8):e2005140.
Yin Y, Garcia MR, Novak AJ, Saunders AM, Ank RS, Nam AS, Fisher LW.
PMID: 30086131; PMCID: PMC6097701
Read MoreAnna (Seung Ha) Nam, MD
Efficient trafficking of acidic proteins out of the endoplasmic reticulum involves a conserved amino terminal IleProVal (IPV)-like tripeptide motif
Connect Tissue Res. 2014 Aug;55 Suppl 1:138-41.
Nam AS, Yin Y, von Marschall Z, Fisher LW.
PMID: 24844412; PMCID: PMC4153534
Read MoreAnna (Seung Ha) Nam, MD
Pim1 permits generation and survival of CD4+ T cells in the absence of γc cytokine receptor signaling
Eur J Immunol. 2013 Sep;43(9):2283-94.
Linowes BA, Ligons DL, Nam AS, Hong C, Keller HR, Tai X, Luckey MA, Park JH.
PMID: 23712827
Read MoreAnna (Seung Ha) Nam, MD
Interleukin-6 expands homeostatic space for peripheral T cells
Cytokine. 2013 Nov;64(2):532-40.
Hong C, Nam AS, Keller HR, Ligons DL, Park JY, Yoon HW, Park JJ, Luckey MA, Park JH.
PMID: 23988623; PMCID: PMC3806195
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