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Laboratory of Neoplastic Hematopoiesis

Anna (Seung Ha) Nam, MD, Principal Investigator 

The Nam Lab seeks to decipher the genotype-to-phenotype relationships in neoplastic blood development. In particular, we recognize that somatic mutations alone do not fully explain cancer phenotypes and seek to define the non-genetic modulators of disease states. For example, our work in myeloproliferative neoplasms demonstrated that the transcriptional impact of somatic mutations varies as a function of cell identity. Thus, our goal is to understand how non-genetic modifiers of somatic mutation impact (such as cell identity, epigenetics and microenvironment) may dictate disease states and patient outcomes. Our lab focuses on developing single-cell multi-omics technologies and computational algorithms to address these questions directly in human hematopoiesis. In this way, we reveal fundamental concepts of tumorigenesis and evolution, as well as identify specific therapeutic targets for translational impact.

Active Projects

  • Modulation of hematopoietic stem cells and microenvironment through cytokine signaling
  • Clonal hematopoiesis and determinants of malignant transformation
  • Lineage plasticity as a mode of therapy resistance

Active Grants

  • Defining malignant hematopoiesis via single-cell multi-omics
    National Institutes of Health (NIH) Early Independence Award
    PI: Anna (Seung Ha) Nam, MD
  • Defining the impact of somatic mutations on human hematopoiesis via single-cell multi-omics
    Burroughs Wellcome Fund Career Awards for Medical Scientists
    PI: Anna (Seung Ha) Nam, MD

 

More about the Nam Lab

Selected Publications

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Anna (Seung Ha) Nam, MD

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

Nature. 2019 Jul;571(7765):355-360. 

Nam AS, Kim KT, Chaligne R, Izzo F, Ang C, Taylor J, Myers RM, Abu-Zeinah G, Brand R, Omans ND, Alonso A, Sheridan C, Mariani M, Dai X, Harrington E, Pastore A, Cubillos-Ruiz JR, Tam W, Hoffman R, Rabadan R, Scandura JM, Abdel-Wahab O, Smibert P, Landau DA.

PMID: 31270458; PMCID: PMC6782071

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Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Anna (Seung Ha) Nam, MD

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Nat Rev Genet. 2020 Aug 17. Review Article.

Nam AS, Chaligne R, Landau DA.

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DNA methylation disruption reshapes the hematopoietic differentiation landscape

Anna (Seung Ha) Nam, MD

DNA methylation disruption reshapes the hematopoietic differentiation landscape

Nat Genet. 2020 Apr;52(4):378-387. 

Izzo F, Lee SC, Poran A, Chaligne R, Gaiti F, Gross B, Murali RR, Deochand SD, Ang C, Jones PW, Nam AS, Kim KT, Kothen-Hill S, Schulman RC, Ki M, Lhoumaud P, Skok JA, Viny AD, Levine RL, Kenigsberg E, Abdel-Wahab O, Landau DA.

PMID: 32203468; PMCID: PMC7216752

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Exploring tumor clonal evolution in bone marrow of patients with diffuse large B-cell lymphoma by deep IGH sequencing and its potential relevance in relapse

Anna (Seung Ha) Nam, MD

Exploring tumor clonal evolution in bone marrow of patients with diffuse large B-cell lymphoma by deep IGH sequencing and its potential relevance in relapse

Blood Cancer J. 2019 Aug 21;9(9):69. 

Ma J, Redmond D, Miyaguchi A, Nam AS, Nie K, Mathew S, Elemento O, Tam W.

PMID: 31434873; PMCID: PMC6704167

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Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum

Anna (Seung Ha) Nam, MD

Surf4 (Erv29p) binds amino-terminal tripeptide motifs of soluble cargo proteins with different affinities, enabling prioritization of their exit from the endoplasmic reticulum

PLoS Biol. 2018 Aug 7;16(8):e2005140.

Yin Y, Garcia MR, Novak AJ, Saunders AM, Ank RS, Nam AS, Fisher LW.

PMID: 30086131; PMCID: PMC6097701

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Efficient trafficking of acidic proteins out of the endoplasmic reticulum involves a conserved amino terminal IleProVal (IPV)-like tripeptide motif

Anna (Seung Ha) Nam, MD

Efficient trafficking of acidic proteins out of the endoplasmic reticulum involves a conserved amino terminal IleProVal (IPV)-like tripeptide motif

Connect Tissue Res. 2014 Aug;55 Suppl 1:138-41. 

Nam AS, Yin Y, von Marschall Z, Fisher LW.

PMID: 24844412; PMCID: PMC4153534

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Pim1 permits generation and survival of CD4+ T cells in the absence of γc cytokine receptor signaling

Anna (Seung Ha) Nam, MD

Pim1 permits generation and survival of CD4+ T cells in the absence of γc cytokine receptor signaling

Eur J Immunol. 2013 Sep;43(9):2283-94. 

Linowes BA, Ligons DL, Nam AS, Hong C, Keller HR, Tai X, Luckey MA, Park JH. 

PMID: 23712827

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Interleukin-6 expands homeostatic space for peripheral T cells

Anna (Seung Ha) Nam, MD

Interleukin-6 expands homeostatic space for peripheral T cells

Cytokine. 2013 Nov;64(2):532-40. 

Hong C, Nam AS, Keller HR, Ligons DL, Park JY, Yoon HW, Park JJ, Luckey MA, Park JH.

PMID: 23988623; PMCID: PMC3806195

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