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Jessica Tyler, PhD, Principal Investigator
Dr. Tyler’s laboratory focuses on discovering the mechanistic basis of the epigenetic regulation of aging, genomic integrity and gene expression. Our studies use a combination of molecular genetics in budding yeast, tissue culture studies, biochemistry and next generation sequencing approaches. The proteins and processes that we study are so fundamentally conserved through eukaryotic evolution, that we can take advantage of the strengths of the highly genetically malleable yeast system to guide our studies in human cells. In addition to learning how chromatin regulates fundamental processes in the cell, our studies are helping us to understand how defects in the chromatin structure lead to gene dysfunction and genomic instability, in turn causing aging and disease states including cancer.
Active Projects
- Role of chromatin structure in maintaining genomic stability
- Attaining longevity via chromatin dynamics
- Discovering the mechanism of chromatin assembly
Active Grants
- Discovering the molecular mechanisms that determine replicative lifespan
PI: Jessica Tyler, PhD
National Institutes of Health (NIH) Research Grant - Chromatin’s Role in the Repair of Radiation-induced Damage
PI: Jessica Tyler, PhD
National Cancer Institute (NIH) - Chromatin Assembly and Function
PI: Jessica Tyler, PhD
National Institutes of Health (NIH) Research Grant
Selected Publications
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression
Jessica K. Tyler, PhD
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression
Cell Rep. 2014 Aug 7;8(3):807-17.
Castillo A, Paul A, Sun B, Huang TH, Wang Y, Yazinski SA, Tyler J, Li L, You MJ, Zou L, Yao J, Wang B.
PMID: 25066119; PMCID: PMC4149256.
Read MoreAcetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair
Jessica K. Tyler, PhD
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair
Cell. 2008 Jul 25;134(2):231-43.
Chen CC, Carson JJ, Feser J, Tamburini B, Zabaronick S, Linger J, Tyler JK.
PMID: 18662539; PMCID: PMC2610811
Read MoreMOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice
Jessica K. Tyler, PhD
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice
Cell Rep. 2014 Jul 10;8(1):177-89.
Gupta A, Hunt CR, Hegde ML, Chakraborty S, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK.
Erratum in: Cell Rep. 2014 Jul 10;8(1):319.
PMID: 24953651; PMCID: PMC4300955.
Read MoreThe conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability
Jessica K. Tyler, PhD
The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability
Epigenetics Chromatin. 2012 Apr 27;5(1):5.
Chavez MS, Scorgie JK, Dennehey BK, Noone S, Tyler JK, Churchill ME.
PMID: 22541333; PMCID: PMC3439350
Read MoreBinding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation
Jessica K. Tyler, PhD
Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation
Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1072-81.
Das C, Roy S, Namjoshi S, Malarkey CS, Jones DN, Kutateladze TG, Churchill ME, Tyler JK.
PMID: 24616510; PMCID: PMC3970516
Read MoreNucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging
Jessica K. Tyler, PhD
Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging
Genes Dev. 2014 Feb 15;28(4):396-408.
Hu Z, Chen K, Xia Z, Chavez M, Pal S, Seol JH, Chen CC, Li W, Tyler JK.
PMID: 24532716; PMCID: PMC3937517
Read MoreMitotic phosphorylation of histone H3 threonine 80
Jessica K. Tyler, PhD
Mitotic phosphorylation of histone H3 threonine 80
Cell Cycle. 2014;13(3):440-52.
Hammond SL, Byrum SD, Namjoshi S, Graves HK, Dennehey BK, Tackett AJ, Tyler JK.
PMID: 24275038; PMCID: PMC3956540
Read MoreThe C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4
Jessica K. Tyler, PhD
The C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4
Mol Cell Biol. 2013 Feb;33(3):605-21.
Dennehey BK, Noone S, Liu WH, Smith L, Churchill ME, Tyler JK.
PMID: 23184661; PMCID: PMC3666882
Read MoreDANPOS: dynamic analysis of nucleosome position and occupancy by sequencing
Jessica K. Tyler, PhD
DANPOS: dynamic analysis of nucleosome position and occupancy by sequencing
Genome Res. 2013 Feb;23(2):341-51.
Chen K, Xi Y, Pan X, Li Z, Kaestner K, Tyler J, Dent S, He X, Li W.
PMID: 23193179; PMCID: PMC3561875
Read MoreElevated histone expression promotes life span extension
Jessica K. Tyler, PhD
Elevated histone expression promotes life span extension
Mol Cell. 2010 Sep 10;39(5):724-35.
Feser J, Truong D, Das C, Carson JJ, Kieft J, Harkness T, Tyler JK.
PMID: 20832724; PMCID: PMC3966075
Read MoreChaperoning histones during DNA replication and repair
Jessica K. Tyler, PhD
Chaperoning histones during DNA replication and repair
Cell. 2010 Jan 22;140(2):183-95.
Ransom M, Dennehey BK, Tyler JK.
PMID: 20141833; PMCID: PMC3433953
Read MoreCBP/p300-mediated acetylation of histone H3 on lysine 56
Jessica K. Tyler, PhD
CBP/p300-mediated acetylation of histone H3 on lysine 56
Nature. 2009 May 7;459(7243):113-7.
Das C, Lucia MS, Hansen KC, Tyler JK.
Erratum in: Nature. 2009 Aug 27;460(7259):1164.
PMID: 19270680; PMCID: PMC2756583
Read MoreAcetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation
Jessica K. Tyler, PhD
Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9000-5.
Williams SK, Truong D, Tyler JK.
PMID: 18577595; PMCID: PMC2449354
Read MoreStructural basis for the histone chaperone activity of Asf1
Jessica K. Tyler, PhD
Structural basis for the histone chaperone activity of Asf1
Cell. 2006 Nov 3;127(3):495-508.
English CM, Adkins MW, Carson JJ, Churchill ME, Tyler JK.
PMID: 17081973; PMCID: PMC2981792.
Read MoreTranscriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions
Jessica K. Tyler, PhD
Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions
Mol Cell. 2006 Feb 3;21(3):405-16.
Adkins MW, Tyler JK.
Erratum in: Mol Cell. 2006 Apr 7;22(1):147-8.
PMID: 16455495
Read MoreThe histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase
Jessica K. Tyler, PhD
The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase
Mol Cell Biol. 2005 Jan;25(2):652-60.
Zabaronick SR, Tyler JK.
Erratum in: Mol Cell Biol. 2005 Apr;25(7):2871.
PMID: 15632066; PMCID: PMC543432
Read MoreActivation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1
Jessica K. Tyler, PhD
Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1
Mol Cell Biol. 2004 Dec;24(23):10313-27.
Ramey CJ, Howar S, Adkins M, Linger J, Spicer J, Tyler JK.
PMID: 15542840; PMCID: PMC529054
Read MoreChromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes
Jessica K. Tyler, PhD
Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes
Mol Cell. 2004 Jun 4;14(5):657-66.
Adkins MW, Howar SR, Tyler JK.
PMID: 15175160
Read MoreThe RCAF complex mediates chromatin assembly during DNA replication and repair
Jessica K. Tyler, PhD
The RCAF complex mediates chromatin assembly during DNA replication and repair
Nature. 1999 Dec 2;402(6761):555-60.
Tyler JK, Adams CR, Chen SR, Kobayashi R, Kamakaka RT, Kadonaga JT.
PMID: 10591219
Read MoreThe "dark side" of chromatin remodeling: repressive effects on transcription
Jessica K. Tyler, PhD
The "dark side" of chromatin remodeling: repressive effects on transcription
Cell. 1999 Nov 24;99(5):443-6.
Tyler JK, Kadonaga JT.
PMID: 10589670
Read More