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Our goal is to understand the mechanism for cell cycle control of immunity and hematologic malignancies and to translate this knowledge into novel cell cycle-based cancer therapy. Following our discovery that CDK4/CDK6 control B cell immunity, we are investigating CDK control of cancer metabolism and defining genes that mediate clinical response to our hypothesis- driven therapy targeting CDK4/CDK6 in lymphoma and myeloma.
Maurizio DiLiberto, PhD, Susan Mathew, PhD, Selina Chen-Kiang, PhD
Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.
Cancer Discov. 2014 Sep;4(9):1022-35.
Chiron D, Di Liberto M, Martin P, Huang X, Sharman J, Blecua P, Mathew S, Vijay P, Eng K, Ali S, Johnson A, Chang B, Ely S, Elemento O, Mason CE, Leonard JP, Chen-Kiang S.
PMID: 25082755; PMCID: PMC4155003
Read MoreMaurizio DiLiberto, PhD, Susan Mathew, PhD, Selina Chen-Kiang, PhD
Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.
Cancer Discov. 2014 Sep;4(9):1022-35.
Chiron D, Di Liberto M, Martin P, Huang X, Sharman J, Blecua P, Mathew S, Vijay P, Eng K, Ali S, Johnson A, Chang B, Ely S, Elemento O, Mason CE, Leonard JP, Chen-Kiang S.
PMID: 25082755; PMCID: PMC4155003
Read MoreSelina Chen-Kiang, PhD
Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity
Leukemia. 2013 Dec;27(12):2341-50.
Zhao X, Lwin T, Zhang X, Huang A, Wang J, Marquez VE, Chen-Kiang S, Dalton WS, Sotomayor E, Tao J.
PMID: 23538750; PMCID: PMC4015113
Read MoreSelina Chen-Kiang, PhD, Maurizio DiLiberto, PhD, Xiangao Huang, PhD
Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.
Cell Cycle. 2013 Jun 15;12(12):1892-900.
Chiron D, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ, Leonard JP, Mason CE, Chen-Kiang S.
PMID: 23676220
Read MoreSelina Chen-Kiang, PhD, Maurizio DiLiberto, PhD, Xiangao Huang, PhD
Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.
Cell Cycle. 2013 Jun 15;12(12):1892-900.
Chiron D, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ, Leonard JP, Mason CE, Chen-Kiang S.
PMID: 23676220
Read MoreSelina Chen-Kiang, PhD, Maurizio DiLiberto, PhD, Xiangao Huang, PhD
Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.
Cell Cycle. 2013 Jun 15;12(12):1892-900.
Chiron D, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ, Leonard JP, Mason CE, Chen-Kiang S.
PMID: 23676220
Read MoreSelina Chen-Kiang, PhD
Novel RNA regulatory mechanisms revealed in the epitranscriptome.
RNA Biol. 2013 Mar;10(3):342-6.
Saletore Y, Chen-Kiang S, Mason CE. Novel RNA regulatory mechanisms revealed in the epitranscriptome.
PMID: 23434792; PMCID: PMC3672275
Read MoreSelina Chen-Kiang, PhD
BiRd (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma
Blood. 2013 Mar 14;121(11):1982-5.
Rossi A, Mark T, Jayabalan D, Christos P, Zafar F, Pekle K, Pearse R, Chen-Kiang S, Coleman M, Niesvizky R.
PMID: 23299315; PMCID: PMC3596960
Read MoreSelina Chen-Kiang, PhD
Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-cell lymphomas
Cancer Cell. 2012 Oct 16;22(4):506-23.
*Zhang, X., *Zhao, X., Fiskus, W., Lin, J., Lwin,T., Rao, R., Zhang, Y., Chan, J.C., Fu, K., Marquez V.E., Chen-Kiang, S., Moscinski, L.C., Seto, E., Dalton, W.S., Wright, K.L., Sotomayor, E., Bhalla, K., and Tao, J. *Equal contributions
PMID: 23079660; PMCID: PMC3973134
Read MoreSelina Chen-Kiang, PhD
Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.
Cancer Cell. 2012 Oct 16;22(4):452-65.
Sawai CM, Freund J, Oh P, Ndiaye-Lobry D, Bretz JC, Strikoudis A, Genesca L, Trimarchi T, Kelliher MA, Clark M, Soulier J, Chen-Kiang S, Aifantis I.
PMID: 23079656
Read MoreMaurizio DiLiberto, PhD, Selina Chen-Kiang, PhD, Xiangao Huang, PhD
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.
Blood. 2012 Aug 2;120(5):1095-106.
Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL 3rd, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S.
PMID: 22718837; PMCID: PMC3412331
Read MoreMaurizio DiLiberto, PhD, Selina Chen-Kiang, PhD, Xiangao Huang, PhD
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.
Blood. 2012 Aug 2;120(5):1095-106.
Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL 3rd, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S.
PMID: 22718837; PMCID: PMC3412331
Read MoreMaurizio DiLiberto, PhD, Selina Chen-Kiang, PhD, Xiangao Huang, PhD
Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.
Blood. 2012 Aug 2;120(5):1095-106.
Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL 3rd, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S.
PMID: 22718837; PMCID: PMC3412331
Read MoreSelina Chen-Kiang, PhD
Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma.
Blood. 2012 May 17;119(20):4597-607.
Leonard JP, LaCasce AS, Smith MR, Noy A, Chirieac LR, Rodig SJ, Yu JQ, Vallabhajosula S, Schoder H, English P, Neuberg DS, Martin P, Millenson MM, Ely SA, Courtney R, Shaik N, Wilner KD, Randolph S, Van den Abbeele AD, Chen-Kiang SY, Yap JT, Shapiro GI.
PMID: 22383795
Read MoreMaurizio DiLiberto, PhD, Xiangao Huang, PhD
MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin.
Clin Cancer Res. 2011 Jul 1;17(13):4309-19.
Nardiello T, Jungbluth AA, Mei A, Diliberto M, Huang X, Dabrowski A, Andrade VC, Wasserstrum R, Ely S, Niesvizky R, Pearse R, Coleman M, Jayabalan DS, Bhardwaj N, Old LJ, Chen-Kiang S, Cho HJ.
PMID: 21565982
Read MoreMaurizio DiLiberto, PhD, Xiangao Huang, PhD
MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin.
Clin Cancer Res. 2011 Jul 1;17(13):4309-19.
Nardiello T, Jungbluth AA, Mei A, Diliberto M, Huang X, Dabrowski A, Andrade VC, Wasserstrum R, Ely S, Niesvizky R, Pearse R, Coleman M, Jayabalan DS, Bhardwaj N, Old LJ, Chen-Kiang S, Cho HJ.
PMID: 21565982
Read MoreXiangao Huang, PhD
Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors.
Blood. 2011 Feb 17;117(7):2179-88.
Bretz J, Garcia J, Huang X, Kang L, Zhang Y, Toellner KM, Chen-Kiang S.
PMID: 21163929
Read MoreSelina Chen-Kiang, PhD
CDK2 phosphorylation of Smad2 disrupts TGF-beta transcriptional regulation in resistant primary bone marrow myeloma cells
J Immunol. 2009 Feb 15;182(4):1810-7.
Baughn LB, Di Liberto M, Niesvizky R, Cho HJ, Jayabalan D, Lane J, Liu F, Chen-Kiang S.
PMID: 19201832
Read MoreSelina Chen-Kiang, PhD
A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model
Cancer Res. 2008 Jul 15;68(14):5519-23.
Menu, E., *Garcia, J., Huang, X., Di Liberto, M., Toogood, P., Chen, I., Vanderkerken, K., and Chen-Kiang, S. *Equal contributions.
PMID: 18632601
Read MoreSelina Chen-Kiang, PhD
BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma
Blood. 2008 Feb 1;111(3):1101-9.
Niesvizky R, Jayabalan DS, Christos PJ, Furst JR, Naib T, Ely S, Jalbrzikowski J, Pearse RN, Zafar F, Pekle K, Larow A, Lent R, Mark T, Cho HJ, Shore T, Tepler J, Harpel J, Schuster MW, Mathew S, Leonard JP, Mazumdar M, Chen-Kiang S, Coleman M.
PMID: 17989313
Read MoreSelina Chen-Kiang, PhD
Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma: overall survival exceeding 7 years with standard therapies
Ann Oncol. 2008 Jul;19(7):1327-30.
Martin P, Chadburn A, Christos P, Furman R, Ruan J, Joyce MA, Fusco E, Glynn P, Elstrom R, Niesvizky R, Feldman EJ, Shore TB, Schuster MW, Ely S, Knowles DM, Chen-Kiang S, Coleman M, Leonard JP.
PubMed PMID: 18349031
Read MoreSelina Chen-Kiang, PhD
Deletions of CDKN2C in multiple myeloma: biological and clinical implications
Clin Cancer Res. 2008 Oct 1;14(19):6033-41.
Leone PE, Walker BA, Jenner MW, Chiecchio L, Dagrada G, Protheroe RK, Johnson DC, Dickens NJ, Brito JL, Else M, Gonzalez D, Ross FM, Chen-Kiang S, Davies FE, Morgan GJ.
PMID: 18829482; PMCID: PMC2581792
Read MoreMaurizio DiLiberto, PhD
Outcome of deferred initial therapy in mantle-cell lymphoma
JCO. 27: 1209-13.(2008)
Martin, P., Chadburn, A., Christos, P., Weil, K., Furman, R.R., Ruan, J., Elstrom, R., Niesvizky, R., Ely, S., Di Liberto, M., Melnick, A., Knowles, D.M., Chen-Kiang, S., Coleman, M., and Leonard, J.P.
PMID: 19188674
Read MoreSelina Chen-Kiang, PhD
A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6
Cancer Res. 2006 Aug 1;66(15):7661-7.
Baughn LB, Di Liberto M, Wu K, Toogood PL, Louie T, Gottschalk R, Niesvizky R, Cho H, Ely S, Moore MA, Chen-Kiang S.
PMID: 16885367.
Read MoreSelina Chen-Kiang, PhD
The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation
Blood. 2005 Jul 1;106(1):167-74.
Jungbluth, A. A., Ely, S., DiLiberto, M., Niesvizky, R., Williamson, B., Frosina, D., Chen, Y. T., Bhardwaj, N., Chen-Kiang, S., Old, L. J., and Cho, H. J.
PMID: 15761016
Read MoreSelina Chen-Kiang, PhD
Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma
Cancer Res. 2005 Dec 15;65(24):11345-53.
*Ely, S., *Di Liberto, M., Niesvizky, R., Baughn, L. B., Cho, H. J., Hatada, E. N., Knowles, D. M., Lane, J., and Chen-Kiang, S. *Equal contributions.
PMID: 16357141
Read MoreSelina Chen-Kiang, PhD
Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1
Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17789-94.
Huang, X., Di Liberto, M., Cunningham, A. F., Kang, L., Cheng, S., Ely, S., Liou, H. C., Maclennan, I. C., and Chen-Kiang, S.
PMID: 15591344
Read MoreSelina Chen-Kiang, PhD
AID is required for c-myc/IgH chromosome translocations in vivo
Cell. 2004 Aug 20;118(4):431-8.
Ramiro, A. R., Jankovic, M., Eisenreich, T., Difilippantonio, S., Chen-Kiang, S., Muramatsu, M., Honjo, T., Nussenzweig, A., and Nussenzweig, M. C.
PMID: 15315756
Read MoreSelina Chen-Kiang, PhD
NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cells
J Immunol. 2003 Jul 15;171(2):761-8.
Hatada, E. N., Do, R. K., Orlofsky, A., Liou, H. C., Prystowsky, M., MacLennan, I. C., Caamano, J., and Chen-Kiang, S.
PMID: 12847243
Read MoreSelina Chen-Kiang, PhD
CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells
Immunity. 2002 Aug;17(2):179-89.
Tourigny, M. R., Ursini-Siegel, J., Lee, H., Toellner, K. M., Cunningham, A. F., Franklin, D. S., Ely, S., Chen, M., Qin, X. F., Xiong, Y., MacLennan, I.C.M and Chen-Kiang, S.
PMID: 12196289
Read MoreSelina Chen-Kiang, PhD
TRAIL/Apo-2 ligand induces primary plasma cell apoptosis
J Immunol. 2002 Nov 15;169(10):5505-13.
Ursini-Siegel, J., Zhang, W., Altmeyer, A., Hatada, E. N., Do, R. K., Yagita, H., and Chen-Kiang, S.
PMID: 12421926
Read MoreSelina Chen-Kiang, PhD
Interaction and functional interference of C/EBPbeta with octamer factors in immunoglobulin gene transcription
Eur J Immunol. 2000 Jan;30(1):174-84.
Hatada, E. N., Chen-Kiang, S., and Scheidereit, C. (2000).
PMID: 10602039
Read MoreSelina Chen-Kiang, PhD
Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response
J Exp Med. 2000 Oct 2;192(7):953-64.
Do, R. K., Hatada, E., Lee, H., Tourigny, M. R., Hilbert, D., and Chen-Kiang, S.
PMID: 11015437
Read MoreSelina Chen-Kiang, PhD
CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
Genes Dev. 1998 Sep 15;12(18):2899-911.
Franklin, D. S., Godfrey, V. L., Lee, H., Kovalev, G. I., Schoonhoven, R., Chen-Kiang, S., Su, L., and Xiong, Y. (1998).
PMID: 9744866
Read MoreSelina Chen-Kiang, PhD
Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6
Immunity. 1997 Jan;6(1):47-56.
Morse, L., Chen, D., Franklin, D., Xiong, Y., and Chen-Kiang, S.
PMID: 9052836
Read MoreSelina Chen-Kiang, PhD
Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B cell terminal differentiation.
Immunity. 1997 Nov;7(5):667-77.
Altmeyer, A., Simmons, R. C., Krajewski, S., Reed, J. C., Bornkamm, G. W., and Chen-Kiang, S.
PMID: 9390690
Read MoreSelina Chen-Kiang, PhD
Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):465-9.
Chen, P. L., Riley, D. J., Chen-Kiang, S., and Lee, W. H
PMID: 8552662
Read MoreSelina Chen-Kiang, PhD
Requirement of serine phosphorylation for formation of STAT-promoter complexes.
Science. 1995 Mar 31;267(5206):1990-4.
Zhang, X., Blenis, J., Li, H. C., Schindler, C., and Chen-Kiang, S.
PMID: 7701321
Read More