Cell Cycle

Maurizio DiLiberto, PhD, Susan Mathew, PhD, Selina Chen-Kiang, PhD

Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.

Cancer Discov. 2014 Sep;4(9):1022-35.

Chiron D, Di Liberto M, Martin P, Huang X, Sharman J, Blecua P, Mathew S, Vijay P, Eng K, Ali S, Johnson A, Chang B, Ely S, Elemento O, Mason CE, Leonard JP, Chen-Kiang S.

PMID: 25082755; PMCID: PMC4155003

Maurizio DiLiberto, PhD, Susan Mathew, PhD, Selina Chen-Kiang, PhD

Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.

Cancer Discov. 2014 Sep;4(9):1022-35.

Chiron D, Di Liberto M, Martin P, Huang X, Sharman J, Blecua P, Mathew S, Vijay P, Eng K, Ali S, Johnson A, Chang B, Ely S, Elemento O, Mason CE, Leonard JP, Chen-Kiang S.

PMID: 25082755; PMCID: PMC4155003

Selina Chen-Kiang, PhD

Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity

Leukemia. 2013 Dec;27(12):2341-50.

Zhao X, Lwin T, Zhang X, Huang A, Wang J, Marquez VE, Chen-Kiang S, Dalton WS, Sotomayor E, Tao J.

PMID: 23538750; PMCID: PMC4015113

Selina Chen-Kiang, PhD, Maurizio DiLiberto, PhD

Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.

Cell Cycle. 2013 Jun 15;12(12):1892-900. 

Chiron D, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ, Leonard JP, Mason CE, Chen-Kiang S.

PMID: 23676220

Selina Chen-Kiang, PhD, Maurizio DiLiberto, PhD

Induction of prolonged early G1 arrest by CDK4/CDK6 inhibition reprograms lymphoma cells for durable PI3Kδ inhibition through PIK3IP1.

Cell Cycle. 2013 Jun 15;12(12):1892-900. 

Chiron D, Martin P, Di Liberto M, Huang X, Ely S, Lannutti BJ, Leonard JP, Mason CE, Chen-Kiang S.

PMID: 23676220

Selina Chen-Kiang, PhD

Novel RNA regulatory mechanisms revealed in the epitranscriptome.

RNA Biol. 2013 Mar;10(3):342-6. 

Saletore Y, Chen-Kiang S, Mason CE. Novel RNA regulatory mechanisms revealed in the epitranscriptome.

PMID: 23434792; PMCID: PMC3672275

Selina Chen-Kiang, PhD

BiRd (clarithromycin, lenalidomide, dexamethasone): an update on long-term lenalidomide therapy in previously untreated patients with multiple myeloma

Blood. 2013 Mar 14;121(11):1982-5.

Rossi A, Mark T, Jayabalan D, Christos P, Zafar F, Pekle K, Pearse R, Chen-Kiang S, Coleman M, Niesvizky R.

PMID: 23299315; PMCID: PMC3596960

Selina Chen-Kiang, PhD

Coordinated silencing of MYC-mediated miR-29 by HDAC3 and EZH2 as a therapeutic target of histone modification in aggressive B-cell lymphomas

Cancer Cell. 2012 Oct 16;22(4):506-23. 

*Zhang, X., *Zhao, X., Fiskus, W., Lin, J., Lwin,T.,  Rao, R., Zhang, Y., Chan, J.C., Fu, K., Marquez V.E.,  Chen-Kiang, S., Moscinski, L.C., Seto, E., Dalton, W.S., Wright, K.L., Sotomayor, E., Bhalla, K., and Tao, J.  *Equal contributions

PMID: 23079660; PMCID: PMC3973134

Selina Chen-Kiang, PhD

Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.

Cancer Cell. 2012 Oct 16;22(4):452-65. 

Sawai CM, Freund J, Oh P, Ndiaye-Lobry D, Bretz JC, Strikoudis A, Genesca L, Trimarchi T, Kelliher MA, Clark M, Soulier J, Chen-Kiang S, Aifantis I.

PMID: 23079656

Maurizio DiLiberto, PhD, Selina Chen-Kiang, PhD

Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.

Blood. 2012 Aug 2;120(5):1095-106. 

Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL 3rd, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S.

PMID: 22718837; PMCID: PMC3412331

Maurizio DiLiberto, PhD, Selina Chen-Kiang, PhD

Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.

Blood. 2012 Aug 2;120(5):1095-106. 

Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL 3rd, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S.

PMID: 22718837; PMCID: PMC3412331

Maurizio DiLiberto, PhD, Selina Chen-Kiang, PhD

Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.

Blood. 2012 Aug 2;120(5):1095-106. 

Huang X, Di Liberto M, Jayabalan D, Liang J, Ely S, Bretz J, Shaffer AL 3rd, Louie T, Chen I, Randolph S, Hahn WC, Staudt LM, Niesvizky R, Moore MA, Chen-Kiang S.

PMID: 22718837; PMCID: PMC3412331

Selina Chen-Kiang, PhD

Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma.

Blood. 2012 May 17;119(20):4597-607.

Leonard JP, LaCasce AS, Smith MR, Noy A, Chirieac LR, Rodig SJ, Yu JQ, Vallabhajosula S, Schoder H, English P, Neuberg DS, Martin P, Millenson MM, Ely SA, Courtney R, Shaik N, Wilner KD, Randolph S, Van den Abbeele AD, Chen-Kiang SY, Yap JT, Shapiro GI.

PMID: 22383795

Maurizio DiLiberto, PhD

MAGE-A inhibits apoptosis in proliferating myeloma cells through repression of Bax and maintenance of survivin.

Clin Cancer Res. 2011 Jul 1;17(13):4309-19. 

Nardiello T, Jungbluth AA, Mei A, Diliberto M, Huang X, Dabrowski A, Andrade VC, Wasserstrum R, Ely S, Niesvizky R, Pearse R, Coleman M, Jayabalan DS, Bhardwaj N, Old LJ, Chen-Kiang S, Cho HJ.

PMID: 21565982

Selina Chen-Kiang, PhD

CDK2 phosphorylation of Smad2 disrupts TGF-beta transcriptional regulation in resistant primary bone marrow myeloma cells

J Immunol. 2009 Feb 15;182(4):1810-7.

Baughn LB, Di Liberto M, Niesvizky R, Cho HJ, Jayabalan D, Lane J, Liu F, Chen-Kiang S.

PMID: 19201832

Selina Chen-Kiang, PhD

A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model

Cancer Res. 2008 Jul 15;68(14):5519-23. 

Menu, E., *Garcia, J., Huang, X., Di Liberto, M., Toogood, P., Chen, I., Vanderkerken, K., and Chen-Kiang, S. *Equal contributions. 

PMID: 18632601

Selina Chen-Kiang, PhD

BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma

Blood. 2008 Feb 1;111(3):1101-9.

Niesvizky R, Jayabalan DS, Christos PJ, Furst JR, Naib T, Ely S, Jalbrzikowski J, Pearse RN, Zafar F, Pekle K, Larow A, Lent R, Mark T, Cho HJ, Shore T, Tepler J, Harpel J, Schuster MW, Mathew S, Leonard JP, Mazumdar M, Chen-Kiang S, Coleman M.

PMID: 17989313

Selina Chen-Kiang, PhD

Intensive treatment strategies may not provide superior outcomes in mantle cell lymphoma: overall survival exceeding 7 years with standard therapies

Ann Oncol. 2008 Jul;19(7):1327-30.

Martin P, Chadburn A, Christos P, Furman R, Ruan J, Joyce MA, Fusco E, Glynn P, Elstrom R, Niesvizky R, Feldman EJ, Shore TB, Schuster MW, Ely S, Knowles DM, Chen-Kiang S, Coleman M, Leonard JP.

PubMed PMID: 18349031

Selina Chen-Kiang, PhD

Deletions of CDKN2C in multiple myeloma: biological and clinical implications

Clin Cancer Res. 2008 Oct 1;14(19):6033-41.

Leone PE, Walker BA, Jenner MW, Chiecchio L, Dagrada G, Protheroe RK, Johnson DC, Dickens NJ, Brito JL, Else M, Gonzalez D, Ross FM, Chen-Kiang S, Davies FE, Morgan GJ.

PMID: 18829482; PMCID: PMC2581792

Maurizio DiLiberto, PhD

Outcome of deferred initial therapy in mantle-cell lymphoma

JCO. 27: 1209-13.(2008)

Martin, P., Chadburn, A., Christos, P., Weil, K., Furman, R.R., Ruan, J., Elstrom, R., Niesvizky, R., Ely,  S., Di Liberto, M., Melnick, A., Knowles, D.M., Chen-Kiang, S., Coleman, M., and Leonard, J.P. 

PMID: 19188674

Selina Chen-Kiang, PhD

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6

Cancer Res. 2006 Aug 1;66(15):7661-7.

Baughn LB, Di Liberto M, Wu K, Toogood PL, Louie T, Gottschalk R, Niesvizky R, Cho H, Ely S, Moore MA, Chen-Kiang S. 

PMID: 16885367.

Selina Chen-Kiang, PhD

The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation

Blood. 2005 Jul 1;106(1):167-74. 

Jungbluth, A. A., Ely, S., DiLiberto, M., Niesvizky, R., Williamson, B., Frosina, D., Chen, Y. T., Bhardwaj, N., Chen-Kiang, S., Old, L. J., and Cho, H. J.

PMID: 15761016

Selina Chen-Kiang, PhD

Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma

Cancer Res. 2005 Dec 15;65(24):11345-53.

*Ely, S., *Di Liberto, M., Niesvizky, R., Baughn, L. B., Cho, H. J., Hatada, E. N., Knowles, D. M., Lane, J., and Chen-Kiang, S. *Equal contributions. 

PMID: 16357141

Selina Chen-Kiang, PhD

Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1

Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17789-94. 

Huang, X., Di Liberto, M., Cunningham, A. F., Kang, L., Cheng, S., Ely, S., Liou, H. C., Maclennan, I. C., and Chen-Kiang, S.

PMID: 15591344

Selina Chen-Kiang, PhD

AID is required for c-myc/IgH chromosome translocations in vivo

Cell. 2004 Aug 20;118(4):431-8.

Ramiro, A. R., Jankovic, M., Eisenreich, T., Difilippantonio, S., Chen-Kiang, S., Muramatsu, M., Honjo, T., Nussenzweig, A., and Nussenzweig, M. C.

PMID: 15315756

Selina Chen-Kiang, PhD

NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cells

J Immunol. 2003 Jul 15;171(2):761-8.

Hatada, E. N., Do, R. K., Orlofsky, A., Liou, H. C., Prystowsky, M., MacLennan, I. C., Caamano, J., and Chen-Kiang, S.

PMID: 12847243

Selina Chen-Kiang, PhD

CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells

Immunity. 2002 Aug;17(2):179-89.

Tourigny, M. R., Ursini-Siegel, J., Lee, H., Toellner, K. M., Cunningham, A. F., Franklin, D. S., Ely, S., Chen, M., Qin, X. F., Xiong, Y., MacLennan, I.C.M and Chen-Kiang, S. 

PMID: 12196289

Selina Chen-Kiang, PhD

TRAIL/Apo-2 ligand induces primary plasma cell apoptosis

J Immunol. 2002 Nov 15;169(10):5505-13.

Ursini-Siegel, J., Zhang, W., Altmeyer, A., Hatada, E. N., Do, R. K., Yagita, H., and Chen-Kiang, S.

PMID: 12421926

Selina Chen-Kiang, PhD

Interaction and functional interference of C/EBPbeta with octamer factors in immunoglobulin gene transcription

Eur J Immunol. 2000 Jan;30(1):174-84.

Hatada, E. N., Chen-Kiang, S., and Scheidereit, C. (2000).

PMID: 10602039

Selina Chen-Kiang, PhD

Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response

J Exp Med. 2000 Oct 2;192(7):953-64.

Do, R. K., Hatada, E., Lee, H., Tourigny, M. R., Hilbert, D., and Chen-Kiang, S.

PMID: 11015437

Selina Chen-Kiang, PhD

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

Genes Dev. 1998 Sep 15;12(18):2899-911.

Franklin, D. S., Godfrey, V. L., Lee, H., Kovalev, G. I., Schoonhoven, R., Chen-Kiang, S., Su, L., and Xiong, Y. (1998).

PMID: 9744866

Selina Chen-Kiang, PhD

Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18(INK4c) and IL-6

Immunity. 1997 Jan;6(1):47-56.

Morse, L., Chen, D., Franklin, D., Xiong, Y., and Chen-Kiang, S.

PMID: 9052836

Selina Chen-Kiang, PhD

Reversal of EBV immortalization precedes apoptosis in IL-6-induced human B cell terminal differentiation.

Immunity. 1997 Nov;7(5):667-77.

Altmeyer, A., Simmons, R. C., Krajewski, S., Reed, J. C., Bornkamm, G. W., and Chen-Kiang, S.

PMID: 9390690

Selina Chen-Kiang, PhD

Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6

Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):465-9.

Chen, P. L., Riley, D. J., Chen-Kiang, S., and Lee, W. H

PMID: 8552662

Selina Chen-Kiang, PhD

Requirement of serine phosphorylation for formation of STAT-promoter complexes.

Science. 1995 Mar 31;267(5206):1990-4.

Zhang, X., Blenis, J., Li, H. C., Schindler, C., and Chen-Kiang, S.

PMID: 7701321