Tobacco constituents are mitogenic for arterial smooth-muscle cells.

TitleTobacco constituents are mitogenic for arterial smooth-muscle cells.
Publication TypeJournal Article
Year of Publication1985
AuthorsBecker CG, Hajjar DP, Hefton JM
JournalAm J Pathol
Date Published1985 Jul
KeywordsAnimals, Antigens, Aorta, Thoracic, Arteries, Cattle, Fibroblasts, Flavonoids, Glycoproteins, In Vitro Techniques, Mitogens, Muscle, Smooth, Vascular, Phenols, Plant Proteins, Plants, Toxic, Polymers, Rutin, Serum Albumin, Bovine, Smoke, Structure-Activity Relationship, Tars, Tobacco

Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.

Alternate JournalAm J Pathol
PubMed ID4014438
PubMed Central IDPMC1887962
Grant ListHL-18828 / HL / NHLBI NIH HHS / United States
Related Faculty: 
David P. Hajjar, Ph.D.

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