|Title||Tobacco constituents are mitogenic for arterial smooth-muscle cells.|
|Publication Type||Journal Article|
|Year of Publication||1985|
|Authors||Becker CG, Hajjar DP, Hefton JM|
|Journal||Am J Pathol|
|Date Published||1985 Jul|
|Keywords||Animals, Antigens, Aorta, Thoracic, Arteries, Cattle, Fibroblasts, Flavonoids, Glycoproteins, In Vitro Techniques, Mitogens, Muscle, Smooth, Vascular, Phenols, Plant Proteins, Plants, Toxic, Polymers, Rutin, Serum Albumin, Bovine, Smoke, Structure-Activity Relationship, Tars, Tobacco|
Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.
|Alternate Journal||Am J Pathol|
|PubMed Central ID||PMC1887962|
|Grant List||HL-18828 / HL / NHLBI NIH HHS / United States|
David P. Hajjar, Ph.D.