Tobacco constituents are mitogenic for arterial smooth-muscle cells.

TitleTobacco constituents are mitogenic for arterial smooth-muscle cells.
Publication TypeJournal Article
Year of Publication1985
AuthorsBecker CG, Hajjar DP, Hefton JM
JournalAm J Pathol
Volume120
Issue1
Pagination1-5
Date Published1985 Jul
ISSN0002-9440
KeywordsAnimals, Antigens, Aorta, Thoracic, Arteries, Cattle, Fibroblasts, Flavonoids, Glycoproteins, In Vitro Techniques, Mitogens, Muscle, Smooth, Vascular, Phenols, Plant Proteins, Plants, Toxic, Polymers, Rutin, Serum Albumin, Bovine, Smoke, Structure-Activity Relationship, Tars, Tobacco
Abstract

Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.

Alternate JournalAm J Pathol
PubMed ID4014438
PubMed Central IDPMC1887962
Grant ListHL-18828 / HL / NHLBI NIH HHS / United States
Related Faculty: 
David P. Hajjar, Ph.D.

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