Studies on the structure and possible function of the RNA "cap" in developing sea urchins.

TitleStudies on the structure and possible function of the RNA "cap" in developing sea urchins.
Publication TypeJournal Article
Year of Publication1977
AuthorsSconzo G, Roccheri MC, Di Liberto M, Giudice G
JournalCell Differ
Volume5
Issue5-6
Pagination323-34
Date Published1977 Mar
ISSN0045-6039
KeywordsAnimals, Base Sequence, Dactinomycin, Embryo, Nonmammalian, Methylation, Nucleic Acid Conformation, RNA, Messenger, Sea Urchins
Abstract

Paracentrotus lividus embryos at the hatching blastula stage very quickly incorporate radioactivity from labeled nucleosides (except uridine) or 32P- or methyl-labeled methionine into a portion of the RNA that has been identified as a "cap". The most probable sequence of this cap is m7G (5') ppp (5')mAmpCp. A very active "capping" and methylation of the "cap" of preexisting RNA molecules was shown to occur at the blastula stage.

DOI10.1016/0045-6039(77)90070-7
Alternate JournalCell Differ
PubMed ID856478
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