| Title | The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2). |
| Publication Type | Journal Article |
| Year of Publication | 1994 |
| Authors | Ohba T, Rennert H, Pfeifer SM, He Z, Yamamoto R, Holt JA, Billheimer JT, Strauss JF |
| Journal | Genomics |
| Volume | 24 |
| Issue | 2 |
| Pagination | 370-4 |
| Date Published | 1994 Nov 15 |
| ISSN | 0888-7543 |
| Keywords | Acetyl-CoA C-Acetyltransferase, Base Sequence, Carrier Proteins, DNA Primers, Humans, Molecular Sequence Data, Plant Proteins, Promoter Regions, Genetic, Sterols, Transcription, Genetic, Tumor Cells, Cultured |
| Abstract | Sterol carrier protein X (SCPx) is a 58-kDa protein that is localized to peroxisomes. The amino acid sequence of the protein suggests that SCPx may function as a thiolase. The gene encoding SCPx also codes for a 15.3-kDa protein called sterol carrier protein 2 (SCP2). Here we report the structure of this gene (SCP2), which spans approximately 80 kb and consists of 16 exons and 15 introns. Multiple transcription start sites were identified. The 5' flanking region has characteristics of other peroxisomal protein promoters, which include the absence of a TATA box and a G+C-enriched region containing several reverse GC boxes. |
| DOI | 10.1006/geno.1994.1630 |
| Alternate Journal | Genomics |
| PubMed ID | 7698762 |
| Grant List | F33 HD-07783 / HD / NICHD NIH HHS / United States HD-06274 / HD / NICHD NIH HHS / United States |
Related Faculty:
Hanna Rennert, Ph.D.