Prostaglandins modulate arterial cholesteryl ester metabolism.

TitleProstaglandins modulate arterial cholesteryl ester metabolism.
Publication TypeJournal Article
Year of Publication1984
AuthorsHajjar DP
JournalEnzyme
Volume32
Issue4
Pagination218-27
Date Published1984
ISSN0013-9432
Keywords6-Ketoprostaglandin F1 alpha, Alprostadil, Animals, Arachidonic Acid, Arachidonic Acids, Arteriosclerosis, Cholesterol, Cholesterol Esters, Cyclic AMP, Dinoprostone, Epoprostenol, Humans, Hydrolysis, Muscle, Smooth, Vascular, Prostaglandins, Prostaglandins E
Abstract

Cholesterol and cholesteryl esters (CE) are the two major classes of lipids which accumulate in arteries during human arteriosclerosis. Mechanisms responsible for this arterial lipid accretion remain to be fully elucidated. In recent years, we have suggested that prostaglandins may have an important role in the modulation of intracellular arterial CE metabolism through their interaction with cyclic nucleotides. This hypothesis was based on observations that arteriosclerotic arteries produce less prostaglandins, particularly prostacyclin, and have altered CE synthetic and hydrolytic activities as compared to uninvolved arteries. This review is a summary of our present knowledge concerning the role of eicosanoids and cyclic nucleotides in the modulation of enzyme activities responsible for arterial CE synthesis and hydrolysis.

DOI10.1159/000469481
Alternate JournalEnzyme
PubMed ID6098442
Grant ListHL-18828 / HL / NHLBI NIH HHS / United States
HL-28179 / HL / NHLBI NIH HHS / United States
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David P. Hajjar, Ph.D.

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