Lipid accumulation and ultrastructural change within the aortic wall during early spontaneous atherogenesis.

TitleLipid accumulation and ultrastructural change within the aortic wall during early spontaneous atherogenesis.
Publication TypeJournal Article
Year of Publication1980
AuthorsHajjar DP, Wight TN, Smith SC
JournalAm J Pathol
Volume100
Issue3
Pagination683-705
Date Published1980 Sep
ISSN0002-9440
KeywordsAge Factors, Animals, Aorta, Aorta, Thoracic, Arteriosclerosis, Celiac Artery, Cholesterol, Cholesterol Esters, Columbidae, Fatty Acids, Nonesterified, Hydrocarbons, Lipid Metabolism, Phospholipids, Triglycerides
Abstract

To identify the initial period and type of lipid accumulation during spontaneous atherosclerosis, quantitative chromatographic profiles of major lipid classes in upper thoracic aortas (non-lesion areas) and celiac artery cushions (lesion areas) were obtained from atherosclerosis-susceptible White Carneau (WC) and atherosclerosis-resistant Show Racer (SR) pigeons from 1 day to 6 months of age. Thoracic aortas of WC and SR pigeons contained similar amounts of cholesterol, nonesterified fatty acids, triacylglycerols, cholesteryl esters, phospholipids, and hydrocarbon at each age studied. However, celiac sites in WCs contained more total lipid than corresponding SR sites at 6 weeks and 6 months of age. This initial increase at 6 weeks in WCs was characterized by invreased concentrations of nonesterified saturated fatty acids. By 6 months of age, WC celiac cushions had greater concentrations of each lipid class except hydrocarbon than did SR cushions. This initial lipid accumulation was accompanied by ultrastructural changes within the arterial wall, which included the presence of extracellular, vesiclelike structures and extensive accumulation of basal lamina-like material between cells. This material was not present in aortic regions that are not predisposed to lesion formation. This material increased by 6 months of age in the enlarging WC fibromuscular intimal cushions. These morphologic changes paralleled the quantitative lipid increases and represented the first morphologic changes detectable at this site. Age-related changes in arterial lipid content and ultrastructure in SRs are different from those related to early spontaneous atherogenesis in WCs.

Alternate JournalAm J Pathol
PubMed ID7416236
PubMed Central IDPMC1903566
Related Faculty: 
David P. Hajjar, Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700