Histidine-rich glycoprotein inhibits the antiproliferative effect of heparin on smooth muscle cells.

TitleHistidine-rich glycoprotein inhibits the antiproliferative effect of heparin on smooth muscle cells.
Publication TypeJournal Article
Year of Publication1987
AuthorsHajjar DP, Boyd DB, Harpel PC, Nachman RL
JournalJ Exp Med
Volume165
Issue3
Pagination908-13
Date Published1987 Mar 01
ISSN0022-1007
KeywordsAnimals, Aorta, Cattle, Cell Division, Cells, Cultured, Heparin, Heparin Antagonists, Muscle, Smooth, Vascular, Proteins
Abstract

Histidine-rich glycoprotein (HRGP), an alpha-glycoprotein in human plasma that is also present in platelets and macrophages, binds heparin with high affinity and neutralizes its anticoagulant activity. We now report that HRGP specifically inhibits the antiproliferative effect of heparin on arterial smooth muscle cells while other heparinoid-binding proteins do not influence mitogenesis. The multicellular inflammatory response to endothelial injury characterized, in part, by the influx of platelets and macrophages, may be associated with HRGP release into the arterial microenvironment. This release of HRGP may allow smooth muscle cell proliferation and atherogenesis by inhibiting the action of endothelial cell-derived heparinoid substances.

DOI10.1084/jem.165.3.908
Alternate JournalJ Exp Med
PubMed ID3819648
PubMed Central IDPMC2188292
Grant ListHL-07029 / HL / NHLBI NIH HHS / United States
HL-18828 / HL / NHLBI NIH HHS / United States
Related Faculty: 
David P. Hajjar, Ph.D.

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