Pathology & Laboratory Medicine

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Viral Oncogenesis

Ethel Cesarman, MD, PhD, Principal Investigator

Our laboratory is involved in studying the process of viral oncogenesis in human cancer. We are performing molecular characterization of AIDS-associated lymphomas and Kaposi’s sarcoma, which are frequently associated with infection by EBV (HHV-4) or KSHV (HHV-8), with the goal of identifying molecular targets and developing improved diagnostic and therapeutic strategies.

Active Projects

  • Analysis the viral proteins that provide survival signals to infected tumor cells
  • Develop mouse models of virus-induced malignancy, using xenografts and genetic engineering.
  • Genomics of lymphomas that occur in association with viral infection.
  • Develop methodologies for improved point-of-care diagnosis viral malignancies in poor resource settings.

Active Grants

  • KS-Detect: Kaposi Sarcoma Herpesvirus Research
    PI: Ethel Cesarman, MD,PhD
    Kenneth Horowitz Family Foundation Research Grant
  • KS-Detect: A solar-powered and smartphone integrated instrument for point-of care diagnosis of Kaposi's sarcoma
    PI: Ethel Cesarman, MD,PhD
    National Institutes of Health (NIH) Research Subgrant
  • Modeling KSHV latency in vivo
    PI: Ethel Cesarman, MD,PhD
    National Cancer Institute (NIH)
  • Laboratory Site Agreement
    PI: Ethel Cesarman, MD,PhD
    The AIDS Malignancy Consortium
  • Targeting vFLIP for the Treatment of KSHV-Associated Malignancies
    PI: Ethel Cesarman, MD,PhD
    National Cancer Institute (NIH)
  • Immunology Research Training Program
    PI: Ethel Cesarman, MD,PhD
    National Institute of Allergy and Infectious Diseases (NIH)
  • Solar-Thermal PCR biosensing assay for the diagnosis of Kaposi’s sarcoma in limited resource settings
    PIs: Ethel Cesarman, MD, PhD, David Erickson, PhD
    Weill Cornell CTSC Seed Funds

Selected Publications

AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma

Ethel Cesarman, MD, PhD

AMC 048: modified CODOX-M/IVAC-rituximab is safe and effective for HIV-associated Burkitt lymphoma

Blood. 2015 Jul 9;126(2):160-6.

Noy A, Lee JY, Cesarman E, Ambinder R, Baiocchi R, Reid E, Ratner L, Wagner-Johnston N, Kaplan L; AIDS Malignancy Consortium.

PMID: 25957391; PMCID: PMC4497960

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The tumor virus landscape of AIDS-related lymphomas

Ethel Cesarman, MD, PhD, Amy Chadburn, MD, Wayne Tam, MD, PhD

The tumor virus landscape of AIDS-related lymphomas

Blood. 2015 May 14;125(20):e14-22.

Arvey A, Ojesina AI, Pedamallu CS, Ballon G, Jung J, Duke F, Leoncini L, De Falco G, Bressman E, Tam W, Chadburn A, Meyerson M, Cesarman E.

PMID: 25827832; PMCID: PMC4432014

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Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells

Ethel Cesarman, MD, PhD, Amy Chadburn, MD

Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells

Blood. 2015 Feb 12;125(7):1061-72.

Reichel J, Chadburn A, Rubinstein PG, Giulino-Roth L, Tam W, Liu Y, Gaiolla R, Eng K, Brody J, Inghirami G, Carlo-Stella C, Santoro A, Rahal D, Totonchy J, Elemento O, Cesarman E, Roshal M.

PMID: 25488972

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Systemic expression of Kaposi sarcoma herpesvirus (KSHV) Vflip in endothelial cells leads to a profound proinflammatory phenotype and myeloid lineage remodeling in vivo

Ethel Cesarman, MD, PhD

Systemic expression of Kaposi sarcoma herpesvirus (KSHV) Vflip in endothelial cells leads to a profound proinflammatory phenotype and myeloid lineage remodeling in vivo

PLoS Pathog. 2015 Jan 21;11(1):e1004581.

Ballon G, Akar G, Cesarman E.

PMID: 25607954; PMCID: PMC4301867

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LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis

Ethel Cesarman, MD, PhD

LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis

J Clin Invest. 2015 Jan;125(1):304-15.

Ma SD, Xu X, Plowshay J, Ranheim EA, Burlingham WJ, Jensen JL, Asimakopoulos F, Tang W, Gulley ML, Cesarman E, Gumperz JE, Kenney SC.

PMID: 25485679; PMCID: PMC4382240

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KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

Ethel Cesarman, MD, PhD

KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo

Cell Cycle. 2014;13(23):3670-84.

Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, Evan GI, Cesarman E, Verschuren EW, Ojala PM.

PMID: 25483078

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FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma.

Ethel Cesarman, MD, PhD

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma.

Blood. 2014 Nov 13;124(20):3118-29.

Vogel MJ, Xie L, Guan H, Tooze RM, Maier T, Kostezka U, Maier HJ, Holzmann K, Chan FC, Steidl C, Reichel JB, Weitzer CD, Gehringer F, Kick AB, Cesarman E, Roshal M, Gascoyne RD, Möller P, Wirth T, Ushmorov A.

PMID: 25232062.

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Detection of Kaposi's sarcoma associated herpesvirus nucleic acids using a smartphone accessory.

Ethel Cesarman, MD, PhD

Detection of Kaposi's sarcoma associated herpesvirus nucleic acids using a smartphone accessory.

Lab Chip. 2014 Oct 7;14(19):3809-16.

Mancuso M, Cesarman E, Erickson D.

PMID: 25117534.

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How do viruses trick B cells into becoming lymphomas?

Ethel Cesarman, MD, PhD

How do viruses trick B cells into becoming lymphomas?

Curr Opin Hematol. 2014 Jul;21(4):358-68.

Cesarman E.

PMID: 24886824; PMCID: PMC4126608

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Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics.

Ethel Cesarman, MD, PhD

Solar thermal polymerase chain reaction for smartphone-assisted molecular diagnostics.

Sci Rep. 2014 Feb 20;4:4137. 

Jiang L, Mancuso M, Lu Z, Akar G, Cesarman E, Erickson D.

PMID: 24553130; PMCID: PMC3929917.

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Gammaherpesviruses and lymphoproliferative disorders.

Ethel Cesarman, MD, PhD

Gammaherpesviruses and lymphoproliferative disorders.

Annu Rev Pathol. 2014;9:349-72.

Cesarman E.

PMID: 24111911.

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Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

Ethel Cesarman, MD, PhD

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

Blood. 2013 Oct 17;122(16):2837-47. 

Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E. 

PMID: 23943653; PMCID: PMC3798998.

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Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

Ethel Cesarman, MD, PhD

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

Blood. 2013 Oct 17;122(16):2837-47. 

Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E. 

PMID: 23943653; PMCID: PMC3798998.

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Pathology of lymphoma in HIV.

Ethel Cesarman, MD, PhD

Pathology of lymphoma in HIV.

Curr Opin Oncol. 2013 Sep;25(5):487-94. 

Cesarman E.

PMID: 23942293

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Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.

Ethel Cesarman, MD, PhD

Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood.

J Exp Med. 2013 Aug 26;210(9):1743-59. 

Byun M, Ma CS, Akçay A, Pedergnana V, Palendira U, Myoung J, Avery DT, Liu Y, Abhyankar A, Lorenzo L, Schmidt M, Lim HK, Cassar O, Migaud M, Rozenberg F, Canpolat N, Aydogan G, Fleckenstein B, Bustamante J, Picard C, Gessain A, Jouanguy E, Cesarman E, Olivier M, Gros P, Abel L, Croft M, Tangye SG, Casanova JL.

PMID: 23897980

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Multiplexed colorimetric detection of Kaposi's sarcoma associated herpesvirus and Bartonella DNA using gold and silver nanoparticles.

Ethel Cesarman, MD, PhD

Multiplexed colorimetric detection of Kaposi's sarcoma associated herpesvirus and Bartonella DNA using gold and silver nanoparticles.

Nanoscale. 2013 Feb 21;5(4):1678-86.

Mancuso M, Jiang L, Cesarman E, Erickson D.

PMID: 23340972

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Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes.

Wayne Tam, MD, PhD, Ethel Cesarman, MD, PhD

Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes.

Blood. 2012 Dec 20;120(26):5181-4.

Giulino-Roth L, Wang K, MacDonald TY, Mathew S, Tam Y, Cronin MT, Palmer G, Lucena-Silva N, Pedrosa F, Pedrosa M, Teruya-Feldstein J, Bhagat G, Alobeid B, Leoncini L, Bellan C, Rogena E, Pinkney KA, Rubin MA, Ribeiro RC, Yelensky R, Tam W, Stephens PJ, Cesarman E.

PMID: 23091298

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A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma.

A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma.

Blood. 2011 May 5;117(18):4852-4.

Giulino L, Mathew S, Ballon G, Chadburn A, Barouk S, Antonicelli G, Leoncini L, Liu YF, Gogineni S, Tam W, Cesarman E.

PMID: 21406721

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Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma.

Ethel Cesarman, MD, PhD

Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma.

J Infect Dis. 2011 Apr 15;203(8):1082-6.

Krown SE, Dittmer DP, Cesarman E.

PMID: 21450998

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Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice.

Kaposi sarcoma herpesvirus (KSHV) vFLIP oncoprotein induces B cell transdifferentiation and tumorigenesis in mice.

J Clin Invest. 2011 Mar;121(3):1141-53.

Ballon G, Chen K, Perez R, Tam W, Cesarman E.

PMID: 21339646; PMCID: PMC3049379

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Kaposi's sarcoma and its associated herpesvirus

Ethel Cesarman, MD, PhD

Kaposi's sarcoma and its associated herpesvirus

Nat Rev Cancer. 2010 Oct;10(10):707-19.

Mesri EA, Cesarman E, Boshoff C.

PMID: 20865011

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Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034.

Ethel Cesarman, MD, PhD

Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034.

J Clin Oncol. 2009 Oct 20;27(30):5039-48. 

Chadburn A, Chiu A, Lee JY, Chen X, Hyjek E, Banham AH, Noy A, Kaplan LD, Sparano JA, Bhatia K, Cesarman E.

PMID: 19752343; PMCID: PMC2799056

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KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor

Ethel Cesarman, MD, PhD

KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor

Blood. 2008 May 1;111(9):4731-40.

Di Bartolo DL, Cannon M, Liu YF, Renne R, Chadburn A, Boshoff C, Cesarman E.

PMID: 18199825; PMCID: PMC2343603

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EBV LMP2A mediated LMP1 signaling and survival of lymphoma cells through TRAF2 regulation

Ethel Cesarman, MD, PhD

EBV LMP2A mediated LMP1 signaling and survival of lymphoma cells through TRAF2 regulation

Blood. 111:3813-3820, 2008.

Guasparri I, Bubman D, Cesarman E

PMID: 18230756

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KSHV vFLIP is essential for the survival of infected lymphoma cells

Ethel Cesarman, MD, PhD

KSHV vFLIP is essential for the survival of infected lymphoma cells

J. Exp. Med. 199:993-1003, 2004.

Guasparri I, Keller SA, Cesarman E

PMID: 15067035

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KSHV vFLIP is essential for the survival of infected lymphoma cells

Ethel Cesarman, MD, PhD

KSHV vFLIP is essential for the survival of infected lymphoma cells

J. Exp. Med. 199:993-1003, 2004.

Guasparri I, Keller SA, Cesarman E

PMID: 15067035

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Kaposi's sarcoma-associated herpesvirus--the high cost of viral survival

Ethel Cesarman, MD, PhD

Kaposi's sarcoma-associated herpesvirus--the high cost of viral survival

N Engl J Med. 349:1107-1109,2003.

Cesarman E.

PMID: 13679522

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Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.

Ethel Cesarman, MD, PhD

Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.

Nature. 1998 Aug 6;394(6693):588-92.

Flore O, Rafii S, Ely S, O'Leary JJ, Hyjek EM, Cesarman E.

PMID: 9707121

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Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

Ethel Cesarman, MD, PhD

Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation

Nature. 1997 Jan 23;385(6614):347-50. 

Arvanitakis L, Geras-Raaka E, Varma A, Gershengorn MC, Cesarman E. 

PMID: 9002520.

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Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas

Ethel Cesarman, MD, PhD, Daniel M. Knowles, MD

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas

N Engl J Med. 1995 May 4;332(18):1186-91.

Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM.

PMID: 7700311

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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

Ethel Cesarman, MD, PhD, Daniel M. Knowles, MD

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.

Science. 1994 Dec 16;266(5192):1865-9.

Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, Moore PS.

PMID: 7997879

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