Pathology & Laboratory Medicine

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Molecular Pathology

Hanna Rennert, PhD, Principal Investigator

Dr. Rennert's primary research interest is the genetics of autosomal dominant polycystic kidney disease (ADPKD). In collaboration with researchers from The Rogosin Institute and Weill Cornell Medicine in NY we established in 2006 a genetic study for the identification of mutations in PKD1 and PKD2 genes in a cohort of patients with ADPKD, and to correlate this mutations with disease characteristics and patient phenotype.

This patient repository can then serve as a source of information regarding either the entire population, or subsets of patients with specifically targeted characteristics.

Active Projects

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD) Data Repository. This repository was established to characterize and track progression of ADPKD phenotype, and to correlate phenotypes with PKD1 and PKD2 genotypes.
  • Pilot study of genetic changes associated with Autosomal Dominant Polycystic Kidney Disease. This research focuses on the identification of somatic PKD genes mutations in renal epithelial cells derived from patients with ADPKD.

Active Grants

  • Autosomal Dominant Polycystic Kidney Disease (ADPKD) Data Repository
    PI: Blumenfeld
    STARR Foundation

Selected Publications

Development and validation of a whole genome amplification long-range PCR sequencing method for ADPKD genotyping of low-level DNA samples.

Hanna Rennert, PhD

Development and validation of a whole genome amplification long-range PCR sequencing method for ADPKD genotyping of low-level DNA samples.

Gene. 2014 Oct 15;550(1):131-5.

Liu G, Tan AY, Michaeel A, Blumenfeld J, Donahue S, Bobb W, Parker T, Levine D, Rennert H.

PMID: 25010725

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Autosomal dominant polycystic kidney disease caused by somatic and germline mosaicism.

Hanna Rennert, PhD

Autosomal dominant polycystic kidney disease caused by somatic and germline mosaicism.

Clin Genet. 2014 Mar 18. [Epub ahead of print] 

Tan AY, Blumenfeld J, Michaeel A, Donahue S, Bobb W, Parker T, Levine D, Rennert H.

PMID: 24641620.

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Molecular diagnosis of autosomal dominant polycystic kidney disease using next-generation sequencing.

Hanna Rennert, PhD

Molecular diagnosis of autosomal dominant polycystic kidney disease using next-generation sequencing.

J Mol Diagn. 2014 Mar;16(2):216-28. 

Tan AY, Michaeel A, Liu G, Elemento O, Blumenfeld J, Donahue S, Parker T, Levine D, Rennert H.

PMID: 24374109; PMCID: PMC3937536

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Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline.

Hanna Rennert, PhD

Urine microRNA as potential biomarkers of autosomal dominant polycystic kidney disease progression: description of miRNA profiles at baseline.

PLoS One. 2014 Jan 29;9(1):e86856.

Ben-Dov IZ, Tan YC, Morozov P, Wilson PD, Rennert H, Blumenfeld JD, Tuschl T.

PMID: 24489795; PMCID: PMC3906110

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Pharmacogenomics and the future of toxicology testing.

Hanna Rennert, PhD

Pharmacogenomics and the future of toxicology testing.

Clin Lab Med. 2012 Sep;32(3):509-23.

Agrawal YP, Rennert H.

PMID: 22939305

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Evaluation of a BK virus viral load assay using the QIAGEN Artus BK Virus RG PCR test.

Hanna Rennert, PhD

Evaluation of a BK virus viral load assay using the QIAGEN Artus BK Virus RG PCR test.

J Clin Virol. 2012 Jul;54(3):260-4. 

Rennert H, Jenkins SG, Azurin C, Sipley J.

PMID: 22494899

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A novel long-range PCR sequencing method for genetic analysis of the entire PKD1 gene.

Hanna Rennert, PhD

A novel long-range PCR sequencing method for genetic analysis of the entire PKD1 gene.

J Mol Diagn. 2012 Jul;14(4):305-13. 

Tan YC, Michaeel A, Blumenfeld J, Donahue S, Parker T, Levine D, Rennert H.

PMID: 22608885

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Development of a novel, and rapid genetic test for autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2 using long-range PCR

Hanna Rennert, PhD

Development of a novel, and rapid genetic test for autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2 using long-range PCR

J Mol. Diag., 14:305-313, 2012.

Tan Y.C., Blumenfeld J., Michaeel A., Donahue S., Parker T., Levine D., and Rennert H

PMID:22608885

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Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs.

Hanna Rennert, PhD

Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs.

Biochim Biophys Acta. 2011 Oct;1812(10):1202-12. 

Tan YC, Blumenfeld J, Rennert H.

PMID: 21392578

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Aberrant PKD2 Splicing Due to a Presumed Novel Missense Mutation in Autosomal Dominant Polycystic Kidney Disease

Hanna Rennert, PhD

Aberrant PKD2 Splicing Due to a Presumed Novel Missense Mutation in Autosomal Dominant Polycystic Kidney Disease

Clin. Genet. 80:287-292, 2011.

Tan Y.C., Blumenfeld J., Michael A., Donahue S., Balina M., Parker T., Levine D. and Rennert H

PMID:21392578

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Kidney function and volume progression in unilateral ADPKD with contralateral renal or agenesis hypoplasia: a case series

Hanna Rennert, PhD

Kidney function and volume progression in unilateral ADPKD with contralateral renal or agenesis hypoplasia: a case series

Am J Kidney Dis., 54(3):450-8, 2009.

Poster D., Kistler A.D., Krauer F., Blumenfeld J., Renenrt H. Weishaupt D., Wuethrich R.P., and Serra A.L

PMID:19515475

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Development of a novel, and efficient molecular diagnostic assay for the autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2

Hanna Rennert, PhD

Development of a novel, and efficient molecular diagnostic assay for the autosomal dominant polycystic kidney disease (ADPKD) genes, PKD1 and PKD2

Hum. Mutat., 30(2):264-73, 2009.

Tan Y.C., Blumenfeld J., Donahue S., Belenkaya R., Parker T., Levine D., Debra G.B. Leonard and Rennert H

PMID:22608885

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Weill Cornell Medicine Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-2700 Fax: (212) 746-8624