Pathology & Laboratory Medicine

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Molecular Gynecologic Pathology

Lora Hedrick Ellenson, MD, Principal Investigator

Endometrial carcinoma is the most common malignancy of the female genital tract. Although it is often thought of as a single disease, there is epidemiological and clinicopathological evidence to support the view that it encompasses two broad categories of malignant epithelial tumors.

Active Projects

  • Genetic mouse models of endometrial carcinoma
  • Molecular genetic analysis of primary human endometrial carcinomas
  • RNAseq analysis to identify genes regulated by the PI3K/PTEN/AKT pathway

Active Grants

  • Origins of Ovarian Carcinoma
    PI: Lora Hedrick Ellenson, MD
    National Institutes of Health (NIH) Research Subgrant
  • Cancer-prone stem cell niches in ovarian and tubal epithelia
    PI: Lora Hedrick Ellenson, MD
    Ovarian Cancer Research Fund (OCRF) - Research Subgrant
  • Mouse Model of Endometrial Tumorigenesis
    PI: Lora Hedrick Ellenson, MD
    National Cancer Institute (NIH)

Selected Publications

Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor α.

Lora H. Ellenson, MD

Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor α.

Am J Pathol. 2012 Jun;180(6):2536-47. 

Joshi A, Wang H, Jiang G, Douglas W, Chan JS, Korach KS, Ellenson LH.

PMID: 22503752

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Adenovirus mediated homozygous endometrial epithelial Pten deletion results in aggressive endometrial carcinoma.

Lora H. Ellenson, MD

Adenovirus mediated homozygous endometrial epithelial Pten deletion results in aggressive endometrial carcinoma.

Exp Cell Res. 2011 Jul 1;317(11):1580-9. 

Joshi A, Ellenson LH.

PMID: 21397598

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Molecular Alterations of EGFR and PIK3CA in uterine serous carcinoma

Lora H. Ellenson, MD

Molecular Alterations of EGFR and PIK3CA in uterine serous carcinoma

Gynecol Oncol. 2009 Jun;113(3):370-3. 

Hayes MP, Douglas W, Ellenson LH.

PMID: 19272638; PMCID: PMC2745284

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