Pathology & Laboratory Medicine

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Macrophages and Tissue Remodeling

Domenick J. Falcone, PhD, Principal Investigator

Research in the laboratory is primarily focused on the mechanisms by which macrophages contribute to the pathogenesis and progression of atherosclerosis and aneurysmal dilation. Complications of these chronic vascular diseases remain a major cause of morbidity and mortality in the United States.

Active Projects

  • Novel therapeutic targets in the regulation of macrophage metalloproteinase -9 expression
  • Regulation of macrophages inflammatory status
  • IL-6-mediated induction of metalloproteinase -9 is modulated by Janus kinase-dependent IL-10 expression in macrophages

Active Grants

  • PGE2 receptors as therapeutic targets in occlusive and aneurysmal vascular disease
    PI: Domenick J. Falcone, PhD
    National Heart Lung and Blood Institute (NIH)
  • Doxycycline for COPD in HIV-infected patients
    Collaborating Investigator: Domenick J. Falcone, PhD
    National Heart Lung and Blood Institute (NIH)

Selected Publications

Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice

Domenick J. Falcone, PhD

Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice

Cancer Prev Res (Phila). 2015 Aug;8(8):751-9.

Bhardwaj P, Du B, Zhou XK, Sue E, Giri D, Harbus MD, Falcone DJ, Hudis CA, Subbaramaiah K, Dannenberg AJ.

PMID: 26038116; PMCID: PMC4526346

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Menopause is a determinant of breast adipose inflammation

Domenick J. Falcone, PhD

Menopause is a determinant of breast adipose inflammation

Cancer Prev Res (Phila). 2015 May;8(5):349-58.

Iyengar NM, Morris PG, Zhou XK, Gucalp A, Giri D, Harbus MD, Falcone DJ, Krasne MD, Vahdat LT, Subbaramaiah K, Morrow M, Hudis CA, Dannenberg AJ.

PMID: 25720743; PMCID: PMC4417434

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Caloric restriction reverses obesity-induced mammary gland inflammation in mice.

Domenick J. Falcone, PhD

Caloric restriction reverses obesity-induced mammary gland inflammation in mice.

Cancer Prev Res (Phila). 2013 Apr;6(4):282-9. 

Bhardwaj P, Du B, Zhou XK, Sue E, Harbus MD, Falcone DJ, Giri D, Hudis CA, Kopelovich L, Subbaramaiah K, Dannenberg AJ.

PMID: 23430756

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The annexin A2/S100A10 system in health and disease: emerging paradigms.

Domenick J. Falcone, PhD

The annexin A2/S100A10 system in health and disease: emerging paradigms.

J Biomed Biotechnol. 2012;2012:406273.

Hedhli N, Falcone DJ, Huang B, Cesarman-Maus G, Kraemer R, Zhai H, Tsirka SE, Santambrogio L, Hajjar KA.

PMID: 23193360

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Matrix metalloproteinase (MMP)-dependent microsomal prostaglandin E synthase (mPGES)-1 expression in macrophages: Role of TNF-α and the EP4 prostanoid receptor

Domenick J. Falcone, PhD

Matrix metalloproteinase (MMP)-dependent microsomal prostaglandin E synthase (mPGES)-1 expression in macrophages: Role of TNF-α and the EP4 prostanoid receptor

J Immunol. 2012 Feb 15;188(4):1970-80.

Khan KM, Kothari P, Du B, Dannenberg AJ, Falcone DJ.

PMID: 22227567

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ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation

Domenick J. Falcone, PhD

ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation

J Exp Med. 2012 Nov 19;209(12):2291-305.

Siao CJ, Lorentz CU, Kermani P, Marinic T, Carter J, McGrath K, Padow VA, Mark W, Falcone DJ, Cohen-Gould L, Parrish DC, Habecker BA, Nykjaer A, Ellenson LH, Tessarollo L, Hempstead BL.

PMID: 23091165; PMCID: PMC3501352

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Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer

Domenick J. Falcone, PhD

Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer

Cancer Prev Res (Phila). 2011 Jul;4(7):1021-9.

Morris PG, Hudis CA, Giri D, Morrow M, Falcone DJ, Zhou XK, Du B, Brogi E, Crawford CB, Kopelovich L, Subbaramaiah K, Dannenberg AJ.

PMID: 21622727; PMCID: PMC3131426

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Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification.

Domenick J. Falcone, PhD

Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification.

Carcinogenesis. 2011 May;32(5):695-702.

Hou Z, Falcone DJ, Subbaramaiah K, Dannenberg AJ.

PMID: 21310944

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Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: Evidence for the role of TNF-∝ and cyclooxygenase-2.

Domenick J. Falcone, PhD

Matrix metalloproteinase (MMP)-1 and MMP-3 induce macrophage MMP-9: Evidence for the role of TNF-∝ and cyclooxygenase-2.

J Immunol. 2009 Dec 15;183(12):8119-27.

Steenport M, Khan KM, Du B, Barnhard SE, Dannenberg AJ, Falcone DJ.

PMID: 19923455; PMCID: PMC3621723

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Tobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: Evidence for an EGFR-dependent mechanism

Domenick J. Falcone, PhD

Tobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: Evidence for an EGFR-dependent mechanism

Cancer Res. 2007 Sep 15;67(18):8966-72.

Du B, Leung H, Khan KM, Miller CG, Subbaramaiah K, Falcone DJ, Dannenberg AJ.

PMID: 17875740

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Targeting PGE2 receptors as an alternative strategy to block COX-2-dependent extracellular matrix-induced MMP-9 expression by macrophages

Domenick J. Falcone, PhD

Targeting PGE2 receptors as an alternative strategy to block COX-2-dependent extracellular matrix-induced MMP-9 expression by macrophages

J Biol Chem. 2006 Feb 10;281(6):3321-8. 

Pavlovic S, Du B, Sakamoto K, Khan KM, Natarajan C, Breyer RM, Dannenberg AJ, Falcone DJ. 

PMID: 16338931

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Extracellular matrix induced cyclooxygenase-2 regulates macrophage proteinase expression

Domenick J. Falcone, PhD

Extracellular matrix induced cyclooxygenase-2 regulates macrophage proteinase expression

J Biol Chem. 2004 May 21;279(21):22039-46. 

Khan KM, Howe LR, Falcone DJ.

PMID: 15024003

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Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: Enhanced expression by macrophages

Domenick J. Falcone, PhD

Annexin II mediates plasminogen-dependent matrix invasion by human monocytes: Enhanced expression by macrophages

Blood. 2004 Jan 1;103(1):317-24.

Brownstein C, Deora AB, Jacovina AT, Weintraub R, Gertler M, Khan KM, Falcone DJ, Hajjar KA.

PMID: 14504107

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Exposure of cryptic domains in the alpha1-chain of laminin-1 by elastase stimulates macrophages urokinase and MMP-9 expression

Domenick J. Falcone, PhD

Exposure of cryptic domains in the alpha1-chain of laminin-1 by elastase stimulates macrophages urokinase and MMP-9 expression

J Biol Chem. 2002 Apr 19;277(16):13778-86.

Faisal Khan KM, Laurie GW, McCaffrey TA, Falcone DJ.

PMID: 11827968

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Myocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload

Domenick J. Falcone, PhD

Myocardial fibrosis in chronic aortic regurgitation: molecular and cellular responses to volume overload

Circulation. 2002 Apr 16;105(15):1837-42.

Borer JS, Truter S, Herrold EM, Falcone DJ, Pena M, Carter JN, Dumlao TF, Lee JA, Supino PG. 

PMID: 11956128

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Nerve growth factor activation of erk-1 and erk-2 induces matrix metalloproteinase expression in vascular smooth muscle cells.

Domenick J. Falcone, PhD

Nerve growth factor activation of erk-1 and erk-2 induces matrix metalloproteinase expression in vascular smooth muscle cells.

J Biol Chem. 2002 Jan 18;277(3):2353-9.

Khan KM, Falcone DJ, Kraemer

PMID: 11698409

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Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II

Domenick J. Falcone, PhD

Plasminogen-mediated matrix invasion and degradation by macrophages is dependent on surface expression of annexin II

Blood. 2001 Feb 1;97(3):777-84. 

Falcone DJ, Borth W, Khan KM, Hajjar KA.

PMID: 11157497

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Selective activation of MAPKerk1/2 by laminin-1 peptide alpha1:Ser2091-Arg2108 regulates macrophage degradative phenotype

Domenick J. Falcone, PhD

Selective activation of MAPKerk1/2 by laminin-1 peptide alpha1:Ser2091-Arg2108 regulates macrophage degradative phenotype

J Biol Chem. 2000 Feb 11;275(6):4492-8.

Khan KM, Falcone DJ.

PMID: 10660623

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Macrophage formation of angiostatin during inflammation: A byproduct of the activation of plasminogen. J

Domenick J. Falcone, PhD

Macrophage formation of angiostatin during inflammation: A byproduct of the activation of plasminogen. J

J Biol Chem. 1998 Nov 20;273(47):31480-5.

Falcone DJ, Khan KM, Layne T, Fernandes L.

PMID: 9813061

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